Top Biotech Institutional P&L

Estimated portfolio P&L ranking for biotech-focused institutions, based on reported 13F stock holdings. Due to the inherent delay in 13F filings and various factors such as stock split adjustments, this ranking is a best-effort estimate and may contain inaccuracies.

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#Institution1M P&L3M P&LHY P&L

1BAKER BROS. ADVISORS LP+17.70%+8.30%+45.19%

2Avoro Capital Advisors LLC+20.55%+10.44%+25.86%

3RTW INVESTMENTS, LP+16.46%+5.45%+12.23%

4RA CAPITAL MANAGEMENT, L.P.+12.34%+7.10%+9.00%

5DEERFIELD MANAGEMENT COMPANY, L.P.+13.69%+6.77%+22.27%

6PERCEPTIVE ADVISORS LLC+16.61%+13.90%+21.81%

7Bellevue Group AG+11.21%-1.83%+14.14%

8ORBIMED ADVISORS LLC+15.30%+5.15%+23.60%

9Darwin Global Management, Ltd.+4.81%-8.07%-2.52%

10Deep Track Capital, LP+14.90%+3.24%+31.41%

11SUVRETTA CAPITAL MANAGEMENT, LLC+18.01%+11.03%+15.35%

12Paradigm Biocapital Advisors LP+18.47%+16.69%+54.63%

13Frazier Life Sciences Management, L.P.+14.12%+7.47%+30.21%

14Siren, L.L.C.+21.80%+18.02%+47.99%

15BRAIDWELL LP+16.80%+9.23%+26.91%

16TCG Crossover Management, LLC+17.57%+20.47%+56.68%

17BVF INC/IL+18.74%+5.93%+54.05%

18Vestal Point Capital, LP+12.73%+20.84%+41.71%

19Fairmount Funds Management LLC+33.91%+21.15%+82.71%

20Soleus Capital Management, L.P.+13.42%+5.71%+28.28%

21Sofinnova Investments, Inc.+10.69%+10.50%+34.68%

22EcoR1 Capital, LLC+12.71%+13.76%+22.16%

23TANG CAPITAL MANAGEMENT LLC+11.70%+7.47%+28.98%

24VR Adviser, LLC+31.31%+29.34%+80.52%

25Integral Health Asset Management, LLC+11.31%+2.29%+14.26%

1BAKER BROS. ADVISORS LP

1M P&L+17.70%

3M P&L+8.30%

HY P&L+45.19%

2Avoro Capital Advisors LLC

1M P&L+20.55%

3M P&L+10.44%

HY P&L+25.86%

3RTW INVESTMENTS, LP

1M P&L+16.46%

3M P&L+5.45%

HY P&L+12.23%

4RA CAPITAL MANAGEMENT, L.P.

1M P&L+12.34%

3M P&L+7.10%

HY P&L+9.00%

5DEERFIELD MANAGEMENT COMPANY, L.P.

1M P&L+13.69%

3M P&L+6.77%

HY P&L+22.27%

6PERCEPTIVE ADVISORS LLC

1M P&L+16.61%

3M P&L+13.90%

HY P&L+21.81%

7Bellevue Group AG

1M P&L+11.21%

3M P&L-1.83%

HY P&L+14.14%

8ORBIMED ADVISORS LLC

1M P&L+15.30%

3M P&L+5.15%

HY P&L+23.60%

9Darwin Global Management, Ltd.

1M P&L+4.81%

3M P&L-8.07%

HY P&L-2.52%

10Deep Track Capital, LP

1M P&L+14.90%

3M P&L+3.24%

HY P&L+31.41%

11SUVRETTA CAPITAL MANAGEMENT, LLC

1M P&L+18.01%

3M P&L+11.03%

HY P&L+15.35%

12Paradigm Biocapital Advisors LP

1M P&L+18.47%

3M P&L+16.69%

HY P&L+54.63%

13Frazier Life Sciences Management, L.P.

1M P&L+14.12%

3M P&L+7.47%

HY P&L+30.21%

14Siren, L.L.C.

1M P&L+21.80%

3M P&L+18.02%

HY P&L+47.99%

1M P&L+16.80%

3M P&L+9.23%

HY P&L+26.91%

16TCG Crossover Management, LLC

1M P&L+17.57%

3M P&L+20.47%

HY P&L+56.68%

1M P&L+18.74%

3M P&L+5.93%

HY P&L+54.05%

18Vestal Point Capital, LP

1M P&L+12.73%

3M P&L+20.84%

HY P&L+41.71%

19Fairmount Funds Management LLC

1M P&L+33.91%

3M P&L+21.15%

HY P&L+82.71%

20Soleus Capital Management, L.P.

1M P&L+13.42%

3M P&L+5.71%

HY P&L+28.28%

21Sofinnova Investments, Inc.

1M P&L+10.69%

3M P&L+10.50%

HY P&L+34.68%

22EcoR1 Capital, LLC

1M P&L+12.71%

3M P&L+13.76%

HY P&L+22.16%

23TANG CAPITAL MANAGEMENT LLC

1M P&L+11.70%

3M P&L+7.47%

HY P&L+28.98%

24VR Adviser, LLC

1M P&L+31.31%

3M P&L+29.34%

HY P&L+80.52%

25Integral Health Asset Management, LLC

1M P&L+11.31%

3M P&L+2.29%

HY P&L+14.26%