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The Analysis of Avoro Capital Advisors LLC's Holdings & P&L

Currently, Avoro Capital Advisors LLC holds 35 types of securities in its portfolio with a total value $10.4B. In the most recent quarter, they have increased their positions in CELC (+3.1M shares, valued at $310.3M), UTHR (+583.8K shares, valued at $284.5M), XBI (+2.1M shares, valued at $256.1M); decreased their positions in RNA (-2.2M shares, valued at $158.0M), ALKS (-840.0K shares, valued at $23.5M), N/A (-275.0K shares, valued at $18.3M); initiated new positions in CELC (+3.1M shares, valued at $310.3M), XBI (+2.1M shares, valued at $256.1M), N/A (+4.3M shares, valued at $175.7M).

1M P&L

+1.7B+20.55%

3M P&L

+939.1M+10.44%

HY P&L

+2.0B+25.86%

P&L figures are estimated based on reported 13F stock holdings and market price changes. They are approximations and may not reflect actual fund performance. Stock split events may also affect the accuracy of these calculations, and we cannot guarantee that all splits have been fully accounted for.

Top Holding Treemap

Top Industries by Value

1Biotechnology7.7B

83.0%

2Drug Manufacturers - Specialty & Generic1.3B

14.2%

3N/A256.1M

2.8%

Top Industries by Stock Count

1Biotechnology27 stocks

90.0%

2Drug Manufacturers - Specialty & Generic2 stocks

6.7%

3N/A1 stocks

3.3%

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Stock Holdings

TickerCompany NameSharesShares △%Event DateReport DateHistory

UTHR UNITED THERAPEUTICS CORP2.6M shares28.87%2025-12-312026-02-17

ASND ASCENDIS PHARMA5.1M shares0.02%2025-12-312026-02-17

MDGL MADRIGAL PHARMACEUTICALS INC1.8M shares-1.39%2025-12-312026-02-17

ARGX ARGENX SE990.0K shares0.00%2025-12-312026-02-17

KRYS KRYSTAL BIOTECH INC2.9M shares4.00%2025-12-312026-02-17

ARROWHEAD PHARMACEUTICALS INC ARROWHEAD PHARMACEUTICALS INC10.6M shares-2.52%2025-12-312026-02-17

KYMR KYMERA THERAPEUTICS INC7.5M shares17.71%2025-12-312026-02-17

GPCR STRUCTURE THERAPEUTICS INC6.6M shares27.16%2025-12-312026-02-17

Sponsored

RNA AVIDITY BIOSCIENCES INC5.5M shares-28.65%2025-12-312026-02-17

CNTA CENTESSA PHARMACEUTICALS PLC14.6M shares34.67%2025-12-312026-02-17

CELC CELCUITY INC3.1M sharesnew addition2025-12-312026-02-17

APLS APELLIS PHARMACEUTICALS INC12.2M shares0.00%2025-12-312026-02-17

VERA VERA THERAPEUTICS INC5.9M shares-5.17%2025-12-312026-02-17

XBI SPDR SERIES TRUST - S&P BIOTECH2.1M sharesnew addition2025-12-312026-02-17

XENE XENON PHARMACEUTICALS INC5.4M shares0.45%2025-12-312026-02-17

TERNS PHARMACEUTICALS INC TERNS PHARMACEUTICALS INC4.3M sharesnew addition2025-12-312026-02-17

Sponsored

RVMD REVOLUTION MEDICINES INC2.2M sharesnew addition2025-12-312026-02-17

QURE UNIQURE NV6.2M shares38.38%2025-12-312026-02-17

SOLENO THERAPEUTICS INC SOLENO THERAPEUTICS INC2.9M shares12.50%2025-12-312026-02-17

OCUL OCULAR THERAPEUTIX INC10.8M shares5.15%2025-12-312026-02-17

TSHA TAYSHA GENE THERAPIES INC21.7M shares0.00%2025-12-312026-02-17

SLNO 2.9M sharesnew addition2025-12-312026-02-17

MNMD 5.0M sharesnew addition2025-12-312026-02-17

MIND MEDICINE (MINDMED) INC MIND MEDICINE (MINDMED) INC5.0M sharesnew addition2025-12-312026-02-17

Sponsored

PTC THERAPEUTICS INC PTC THERAPEUTICS INC685.0K sharesnew addition2025-12-312026-02-17

VRDN VIRIDIAN THERAPEUTICS INC1.5M sharesnew addition2025-12-312026-02-17

ORKA ORUKA THERAPEUTICS INC1.3M shares0.00%2025-12-312026-02-17

ALKS ALKERMES PLC1.4M shares-37.50%2025-12-312026-02-17

APGE APOGEE THERAPEUTICS INC500.0K sharesnew addition2025-12-312026-02-17

SEPN SEPTERNA INC1.3M shares0.00%2025-12-312026-02-17

LXEO LEXEO THERAPEUTICS INC3.3M sharesnew addition2025-12-312026-02-17

MNKD MANNKIND CORP4.4M shares-0.55%2025-12-312026-02-17

Sponsored

GHRS GH RESEARCH PLC1.8M sharesnew addition2025-12-312026-02-17

INCY INCYTE CORP135.0K sharesnew addition2025-12-312026-02-17

WHWK WHITEHAWK THERAPEUTICS INC2.8M shares0.00%2025-12-312026-02-17

UTHR

UNITED THERAPEUTICS CORP

28.87%

Shares2.6M

Event2025-12-31

Filed2026-02-17

ASND

ASCENDIS PHARMA

0.02%

Shares5.1M

Event2025-12-31

Filed2026-02-17

MDGL

MADRIGAL PHARMACEUTICALS INC

-1.39%

Shares1.8M

Event2025-12-31

Filed2026-02-17

ARGX

ARGENX SE

0.00%

Shares990.0K

Event2025-12-31

Filed2026-02-17

KRYS

KRYSTAL BIOTECH INC

4.00%

Shares2.9M

Event2025-12-31

Filed2026-02-17

ARROWHEAD PHARMACEUTICALS INC

-2.52%

Shares10.6M

Event2025-12-31

Filed2026-02-17

KYMR

KYMERA THERAPEUTICS INC

17.71%

Shares7.5M

Event2025-12-31

Filed2026-02-17

GPCR

STRUCTURE THERAPEUTICS INC

27.16%

Shares6.6M

Event2025-12-31

Filed2026-02-17

RNA

AVIDITY BIOSCIENCES INC

-28.65%

Shares5.5M

Event2025-12-31

Filed2026-02-17

CNTA

CENTESSA PHARMACEUTICALS PLC

34.67%

Shares14.6M

Event2025-12-31

Filed2026-02-17

CELC

CELCUITY INC

New

Shares3.1M

Event2025-12-31

Filed2026-02-17

APLS

APELLIS PHARMACEUTICALS INC

0.00%

Shares12.2M

Event2025-12-31

Filed2026-02-17

VERA

VERA THERAPEUTICS INC

-5.17%

Shares5.9M

Event2025-12-31

Filed2026-02-17

XBI

SPDR SERIES TRUST - S&P BIOTECH

New

Shares2.1M

Event2025-12-31

Filed2026-02-17

XENE

XENON PHARMACEUTICALS INC

0.45%

Shares5.4M

Event2025-12-31

Filed2026-02-17

TERNS PHARMACEUTICALS INC

New

Shares4.3M

Event2025-12-31

Filed2026-02-17

RVMD

REVOLUTION MEDICINES INC

New

Shares2.2M

Event2025-12-31

Filed2026-02-17

QURE

UNIQURE NV

38.38%

Shares6.2M

Event2025-12-31

Filed2026-02-17

SOLENO THERAPEUTICS INC

12.50%

Shares2.9M

Event2025-12-31

Filed2026-02-17

OCUL

OCULAR THERAPEUTIX INC

5.15%

Shares10.8M

Event2025-12-31

Filed2026-02-17

TSHA

TAYSHA GENE THERAPIES INC

0.00%

Shares21.7M

Event2025-12-31

Filed2026-02-17

SLNO

New

Shares2.9M

Event2025-12-31

Filed2026-02-17

MNMD

New

Shares5.0M

Event2025-12-31

Filed2026-02-17

MIND MEDICINE (MINDMED) INC

New

Shares5.0M

Event2025-12-31

Filed2026-02-17

PTC THERAPEUTICS INC

New

Shares685.0K

Event2025-12-31

Filed2026-02-17

VRDN

VIRIDIAN THERAPEUTICS INC

New

Shares1.5M

Event2025-12-31

Filed2026-02-17

ORKA

ORUKA THERAPEUTICS INC

0.00%

Shares1.3M

Event2025-12-31

Filed2026-02-17

ALKS

ALKERMES PLC

-37.50%

Shares1.4M

Event2025-12-31

Filed2026-02-17

APGE

APOGEE THERAPEUTICS INC

New

Shares500.0K

Event2025-12-31

Filed2026-02-17

SEPN

SEPTERNA INC

0.00%

Shares1.3M

Event2025-12-31

Filed2026-02-17

LXEO

LEXEO THERAPEUTICS INC

New

Shares3.3M

Event2025-12-31

Filed2026-02-17

MNKD

MANNKIND CORP

-0.55%

Shares4.4M

Event2025-12-31

Filed2026-02-17

GHRS

GH RESEARCH PLC

New

Shares1.8M

Event2025-12-31

Filed2026-02-17

INCY

INCYTE CORP

New

Shares135.0K

Event2025-12-31

Filed2026-02-17

WHWK

WHITEHAWK THERAPEUTICS INC

0.00%

Shares2.8M

Event2025-12-31

Filed2026-02-17

Call Option Holdings

ASND Call CallASCENDIS PHARMA50.0K sharesnew addition2025-12-312026-02-17

ASND Call

ASCENDIS PHARMA

New

Shares50.0K

Event2025-12-31

Filed2026-02-17

Put Option Holdings

No put option holdings data available