Sponsored

The Analysis of Siren, L.L.C.'s Holdings & P&L

Currently, Siren, L.L.C. holds 100 types of securities in its portfolio with a total value $3.6B. In the most recent quarter, they have increased their positions in N/A (+1.5M shares, valued at $95.1M), CYTK (+614.0K shares, valued at $40.5M), ERAS (+2.5M shares, valued at $40.2M); decreased their positions in CNTA (-3.0M shares, valued at $118.1M), TNGX (-2.5M shares, valued at $52.5M), DYN (-1.3M shares, valued at $23.1M); initiated new positions in N/A (+1.5M shares, valued at $95.1M), CYTK (+614.0K shares, valued at $40.5M), ELVN (+746.2K shares, valued at $29.3M).

1M P&L

-137.4M-4.04%

3M P&L

+202.9M+6.62%

HY P&L

+447.5M+15.88%

P&L figures are estimated based on reported 13F stock holdings and market price changes. They are approximations and may not reflect actual fund performance. Stock split events may also affect the accuracy of these calculations, and we cannot guarantee that all splits have been fully accounted for.

Top Holding Treemap

Top Industries by Value

1Biotechnology2.7B

92.2%

2Internet Content & Information57.1M

1.9%

3Software - Infrastructure51.7M

1.7%

Top Industries by Stock Count

1Biotechnology59 stocks

62.8%

2Software - Application9 stocks

9.6%

3Software - Infrastructure9 stocks

9.6%

Sponsored

Stock Holdings

TickerCompany NameSharesShares △%Event DateReport DateHistory

SRRK Scholar Rock Holding Corp10.8M shares0.00%2026-03-312026-05-14

KYMR Kymera Therapeutics Inc3.2M shares-3.04%2026-03-312026-05-14

ERAS Erasca Inc11.2M shares28.40%2026-03-312026-05-14

EWTX Edgewise Therapeutics Inc4.4M shares-2.20%2026-03-312026-05-14

ONC BeOne Medicines AG465.0K shares-7.00%2026-03-312026-05-14

TNGX Tango Therapeutics Inc5.7M shares-30.72%2026-03-312026-05-14

BCAX Bicara Therapeutics Inc5.8M shares11.23%2026-03-312026-05-14

RVMD Revolution Medicines Inc1.1M shares-16.79%2026-03-312026-05-14

Sponsored

Arrowhead Pharmaceuticals Inc Arrowhead Pharmaceuticals Inc1.6M shares7.66%2026-03-312026-05-14

Veradermics Inc Veradermics Inc1.5M sharesnew addition2026-03-312026-05-14

XENE Xenon Pharmaceuticals Inc1.3M shares62.23%2026-03-312026-05-14

OLMA Olema Pharmaceuticals Inc4.8M shares44.12%2026-03-312026-05-14

CRNX Crinetics Pharmaceuticals Inc1.9M shares26.27%2026-03-312026-05-14

LXRX Lexicon Pharmaceuticals Inc44.3M shares13.84%2026-03-312026-05-14

COGT Cogent Biosciences Inc1.7M shares4.91%2026-03-312026-05-14

STOK Stoke Therapeutics Inc2.0M shares-11.21%2026-03-312026-05-14

Sponsored

RCUS Arcus Biosciences Inc3.0M shares0.00%2026-03-312026-05-14

GPCR Structure Therapeutics Inc1.3M shares23.18%2026-03-312026-05-14

IRON Disc Medicine Inc988.4K shares0.00%2026-03-312026-05-14

RYTM Rhythm Pharmaceuticals Inc725.5K shares45.11%2026-03-312026-05-14

Solid Biosciences Inc Solid Biosciences Inc7.7M shares0.00%2026-03-312026-05-14

SEPN Septerna Inc2.0M shares0.00%2026-03-312026-05-14

CNTA Centessa Pharmaceuticals PLC1.1M shares-73.84%2026-03-312026-05-14

SYRE Spyre Therapeutics Inc818.6K shares0.00%2026-03-312026-05-14

Sponsored

CYTK Cytokinetics Inc614.0K sharesnew addition2026-03-312026-05-14

DYN Dyne Therapeutics, Inc2.2M shares-36.36%2026-03-312026-05-14

TSHA Taysha Gene Therapies Inc8.8M shares-12.83%2026-03-312026-05-14

Dbv Technologies SA Dbv Technologies SA1.9M shares0.00%2026-03-312026-05-14

ORIC Oric Pharmaceuticals Inc3.0M shares197.57%2026-03-312026-05-14

enGene Holdings Inc enGene Holdings Inc5.3M shares57.46%2026-03-312026-05-14

PVLA Palvella Therapeutics Inc257.5K shares243.31%2026-03-312026-05-14

TBLA Taboola.com Ltd10.0M shares0.00%2026-03-312026-05-14

Sponsored

ELVN Enliven Therapeutics Inc746.2K sharesnew addition2026-03-312026-05-14

DNLI Denali Therapeutics Inc1.4M shares0.00%2026-03-312026-05-14

RELY Remitly Global Inc1.5M shares-4.63%2026-03-312026-05-14

Damora Therapeutics Inc Damora Therapeutics Inc900.0K sharesnew addition2026-03-312026-05-14

ZURA Zura Bio Ltd3.7M shares187.30%2026-03-312026-05-14

ANNX Annexon Inc4.0M sharesnew addition2026-03-312026-05-14

TRVI Trevi Therapeutics Inc1.8M shares-21.86%2026-03-312026-05-14

RAPP Rapport Therapeutics Inc641.5K shares-9.46%2026-03-312026-05-14

Sponsored

Alphabet Inc Alphabet Inc65.7K shares217.36%2026-03-312026-05-14

FULC Fulcrum Therapeutics Inc2.4M shares20.51%2026-03-312026-05-14

WVE WAVE Life Sciences Ltd2.5M shares0.00%2026-03-312026-05-14

Definium Therapeutics Inc Definium Therapeutics Inc919.5K sharesnew addition2026-03-312026-05-14

AMLX Amylyx Pharmaceuticals Inc1.2M sharesnew addition2026-03-312026-05-14

CGEM Cullinan Therapeutics Inc1.2M shares0.00%2026-03-312026-05-14

NMRA Neumora Therapeutics Inc8.5M shares35.13%2026-03-312026-05-14

QURE Uniqure NV1.0M sharesnew addition2026-03-312026-05-14

Sponsored

CTMX CytomX Therapeutics Inc3.5M sharesnew addition2026-03-312026-05-14

NVDA NVIDIA Corp89.1K shares137.66%2026-03-312026-05-14

SLN Silence Therapeutics PLC2.9M shares0.00%2026-03-312026-05-14

MSFT Microsoft Corp41.4K shares175.87%2026-03-312026-05-14

Monopar Therapeutics Inc Monopar Therapeutics Inc270.1K shares27.24%2026-03-312026-05-14

TSM Taiwan Semiconductor Manufacturing Co Ltd42.2K shares52.35%2026-03-312026-05-14

SION Sionna Therapeutics Inc300.0K shares0.00%2026-03-312026-05-14

NBIS Nebius Group NV113.6K shares49.06%2026-03-312026-05-14

Sponsored

RZLT Rezolute Inc3.3M sharesnew addition2026-03-312026-05-14

Inhibikase Therapeutics Inc Inhibikase Therapeutics Inc5.8M shares0.00%2026-03-312026-05-14

AMZN Amazon.com Inc46.6K shares-9.43%2026-03-312026-05-14

Generate Biomedicines Inc Generate Biomedicines Inc736.1K sharesnew addition2026-03-312026-05-14

MapLight Therapeutics Inc MapLight Therapeutics Inc450.0K shares0.00%2026-03-312026-05-14

NOW ServiceNow Inc87.1K shares144.43%2026-03-312026-05-14

CRWD CrowdStrike Holdings Inc23.1K shares39.82%2026-03-312026-05-14

PDD PDD Holdings Inc83.4K shares31.55%2026-03-312026-05-14

Sponsored

TSLA Tesla Inc21.5K shares1333.33%2026-03-312026-05-14

NBP NovaBridge Biosciences3.0M shares0.00%2026-03-312026-05-14

BCYC Bicycle Therapeutics PLC1.6M shares-22.45%2026-03-312026-05-14

WHWK Whitehawk Therapeutics Inc2.1M shares0.00%2026-03-312026-05-14

Tenax Therapeutics Inc Tenax Therapeutics Inc427.1K shares0.00%2026-03-312026-05-14

vTv Therapeutics Inc vTv Therapeutics Inc163.0K shares0.00%2026-03-312026-05-14

DDOG Datadog Inc54.3K shares49.07%2026-03-312026-05-14

FROG Jfrog Ltd128.8K shares37.60%2026-03-312026-05-14

Sponsored

DT Dynatrace Inc150.0K shares30.18%2026-03-312026-05-14

WK Workiva Inc92.5K shares16.91%2026-03-312026-05-14

ABSI Absci Corp1.8M sharesnew addition2026-03-312026-05-14

IVVD Invivyd Inc4.0M shares0.00%2026-03-312026-05-14

Satellos Bioscience Inc Satellos Bioscience Inc892.1K sharesnew addition2026-03-312026-05-14

IONQ IONQ Inc170.0K shares0.00%2026-03-312026-05-14

Broadcom Inc Broadcom Inc15.0K shares114.29%2026-03-312026-05-14

Agomab Therapeutics NV Agomab Therapeutics NV411.3K sharesnew addition2026-03-312026-05-14

Sponsored

CLBT Cellebrite DI Ltd311.5K shares107.70%2026-03-312026-05-14

SEER Seer Inc2.5M shares-38.53%2026-03-312026-05-14

KRRO Korro Bio Inc347.7K shares0.00%2026-03-312026-05-14

AGEN Agenus Inc1.1M shares0.00%2026-03-312026-05-14

FHTX Foghorn Therapeutics Inc720.7K shares0.00%2026-03-312026-05-14

Forgent Power Solutions, Inc Forgent Power Solutions, Inc100.0K sharesnew addition2026-03-312026-05-14

KLRS Kalaris Therapeutics Inc435.8K shares0.00%2026-03-312026-05-14

GTLB GitLab Inc100.0K shares1.01%2026-03-312026-05-14

Sponsored

MU Micron Technology Inc6.0K sharesnew addition2026-03-312026-05-14

MNDY monday.com Ltd25.0K shares47.06%2026-03-312026-05-14

GOSS Gossamer Bio Inc5.2M shares0.00%2026-03-312026-05-14

AS Amer Sports Inc50.0K sharesnew addition2026-03-312026-05-14

BEKE KE Holdings Inc100.0K shares-31.03%2026-03-312026-05-14

IREN IREN Ltd43.1K shares0.00%2026-03-312026-05-14

RANI Rani Therapeutics Holdings Inc2.0M shares0.00%2026-03-312026-05-14

Aeva Technologies Inc Aeva Technologies Inc110.0K sharesnew addition2026-03-312026-05-14

Sponsored

Medline Inc Medline Inc25.0K shares-66.67%2026-03-312026-05-14

FIG Figma Inc50.0K shares100.00%2026-03-312026-05-14

PRMB Primo Brands Corp50.0K shares-33.33%2026-03-312026-05-14

NU Nu Holdings Ltd.25.0K sharesnew addition2026-03-312026-05-14

SRRK

Scholar Rock Holding Corp

0.00%

Shares10.8M

Event2026-03-31

Filed2026-05-14

KYMR

Kymera Therapeutics Inc

-3.04%

Shares3.2M

Event2026-03-31

Filed2026-05-14

ERAS

Erasca Inc

28.40%

Shares11.2M

Event2026-03-31

Filed2026-05-14

EWTX

Edgewise Therapeutics Inc

-2.20%

Shares4.4M

Event2026-03-31

Filed2026-05-14

ONC

BeOne Medicines AG

-7.00%

Shares465.0K

Event2026-03-31

Filed2026-05-14

TNGX

Tango Therapeutics Inc

-30.72%

Shares5.7M

Event2026-03-31

Filed2026-05-14

BCAX

Bicara Therapeutics Inc

11.23%

Shares5.8M

Event2026-03-31

Filed2026-05-14

RVMD

Revolution Medicines Inc

-16.79%

Shares1.1M

Event2026-03-31

Filed2026-05-14

Arrowhead Pharmaceuticals Inc

7.66%

Shares1.6M

Event2026-03-31

Filed2026-05-14

Veradermics Inc

New

Shares1.5M

Event2026-03-31

Filed2026-05-14

XENE

Xenon Pharmaceuticals Inc

62.23%

Shares1.3M

Event2026-03-31

Filed2026-05-14

OLMA

Olema Pharmaceuticals Inc

44.12%

Shares4.8M

Event2026-03-31

Filed2026-05-14

CRNX

Crinetics Pharmaceuticals Inc

26.27%

Shares1.9M

Event2026-03-31

Filed2026-05-14

LXRX

Lexicon Pharmaceuticals Inc

13.84%

Shares44.3M

Event2026-03-31

Filed2026-05-14

COGT

Cogent Biosciences Inc

4.91%

Shares1.7M

Event2026-03-31

Filed2026-05-14

STOK

Stoke Therapeutics Inc

-11.21%

Shares2.0M

Event2026-03-31

Filed2026-05-14

RCUS

Arcus Biosciences Inc

0.00%

Shares3.0M

Event2026-03-31

Filed2026-05-14

GPCR

Structure Therapeutics Inc

23.18%

Shares1.3M

Event2026-03-31

Filed2026-05-14

IRON

Disc Medicine Inc

0.00%

Shares988.4K

Event2026-03-31

Filed2026-05-14

RYTM

Rhythm Pharmaceuticals Inc

45.11%

Shares725.5K

Event2026-03-31

Filed2026-05-14

Solid Biosciences Inc

0.00%

Shares7.7M

Event2026-03-31

Filed2026-05-14

SEPN

Septerna Inc

0.00%

Shares2.0M

Event2026-03-31

Filed2026-05-14

CNTA

Centessa Pharmaceuticals PLC

-73.84%

Shares1.1M

Event2026-03-31

Filed2026-05-14

SYRE

Spyre Therapeutics Inc

0.00%

Shares818.6K

Event2026-03-31

Filed2026-05-14

CYTK

Cytokinetics Inc

New

Shares614.0K

Event2026-03-31

Filed2026-05-14

DYN

Dyne Therapeutics, Inc

-36.36%

Shares2.2M

Event2026-03-31

Filed2026-05-14

TSHA

Taysha Gene Therapies Inc

-12.83%

Shares8.8M

Event2026-03-31

Filed2026-05-14

Dbv Technologies SA

0.00%

Shares1.9M

Event2026-03-31

Filed2026-05-14

ORIC

Oric Pharmaceuticals Inc

197.57%

Shares3.0M

Event2026-03-31

Filed2026-05-14

enGene Holdings Inc

57.46%

Shares5.3M

Event2026-03-31

Filed2026-05-14

PVLA

Palvella Therapeutics Inc

243.31%

Shares257.5K

Event2026-03-31

Filed2026-05-14

TBLA

Taboola.com Ltd

0.00%

Shares10.0M

Event2026-03-31

Filed2026-05-14

ELVN

Enliven Therapeutics Inc

New

Shares746.2K

Event2026-03-31

Filed2026-05-14

DNLI

Denali Therapeutics Inc

0.00%

Shares1.4M

Event2026-03-31

Filed2026-05-14

RELY

Remitly Global Inc

-4.63%

Shares1.5M

Event2026-03-31

Filed2026-05-14

Damora Therapeutics Inc

New

Shares900.0K

Event2026-03-31

Filed2026-05-14

ZURA

Zura Bio Ltd

187.30%

Shares3.7M

Event2026-03-31

Filed2026-05-14

ANNX

Annexon Inc

New

Shares4.0M

Event2026-03-31

Filed2026-05-14

TRVI

Trevi Therapeutics Inc

-21.86%

Shares1.8M

Event2026-03-31

Filed2026-05-14

RAPP

Rapport Therapeutics Inc

-9.46%

Shares641.5K

Event2026-03-31

Filed2026-05-14

Alphabet Inc

217.36%

Shares65.7K

Event2026-03-31

Filed2026-05-14

FULC

Fulcrum Therapeutics Inc

20.51%

Shares2.4M

Event2026-03-31

Filed2026-05-14

WVE

WAVE Life Sciences Ltd

0.00%

Shares2.5M

Event2026-03-31

Filed2026-05-14

Definium Therapeutics Inc

New

Shares919.5K

Event2026-03-31

Filed2026-05-14

AMLX

Amylyx Pharmaceuticals Inc

New

Shares1.2M

Event2026-03-31

Filed2026-05-14

CGEM

Cullinan Therapeutics Inc

0.00%

Shares1.2M

Event2026-03-31

Filed2026-05-14

NMRA

Neumora Therapeutics Inc

35.13%

Shares8.5M

Event2026-03-31

Filed2026-05-14

QURE

Uniqure NV

New

Shares1.0M

Event2026-03-31

Filed2026-05-14

CTMX

CytomX Therapeutics Inc

New

Shares3.5M

Event2026-03-31

Filed2026-05-14

NVDA

NVIDIA Corp

137.66%

Shares89.1K

Event2026-03-31

Filed2026-05-14

SLN

Silence Therapeutics PLC

0.00%

Shares2.9M

Event2026-03-31

Filed2026-05-14

MSFT

Microsoft Corp

175.87%

Shares41.4K

Event2026-03-31

Filed2026-05-14

Monopar Therapeutics Inc

27.24%

Shares270.1K

Event2026-03-31

Filed2026-05-14

TSM

Taiwan Semiconductor Manufacturing Co Ltd

52.35%

Shares42.2K

Event2026-03-31

Filed2026-05-14

SION

Sionna Therapeutics Inc

0.00%

Shares300.0K

Event2026-03-31

Filed2026-05-14

NBIS

Nebius Group NV

49.06%

Shares113.6K

Event2026-03-31

Filed2026-05-14

RZLT

Rezolute Inc

New

Shares3.3M

Event2026-03-31

Filed2026-05-14

Inhibikase Therapeutics Inc

0.00%

Shares5.8M

Event2026-03-31

Filed2026-05-14

AMZN

Amazon.com Inc

-9.43%

Shares46.6K

Event2026-03-31

Filed2026-05-14

Generate Biomedicines Inc

New

Shares736.1K

Event2026-03-31

Filed2026-05-14

MapLight Therapeutics Inc

0.00%

Shares450.0K

Event2026-03-31

Filed2026-05-14

NOW

ServiceNow Inc

144.43%

Shares87.1K

Event2026-03-31

Filed2026-05-14

CRWD

CrowdStrike Holdings Inc

39.82%

Shares23.1K

Event2026-03-31

Filed2026-05-14

PDD

PDD Holdings Inc

31.55%

Shares83.4K

Event2026-03-31

Filed2026-05-14

TSLA

Tesla Inc

1333.33%

Shares21.5K

Event2026-03-31

Filed2026-05-14

NBP

NovaBridge Biosciences

0.00%

Shares3.0M

Event2026-03-31

Filed2026-05-14

BCYC

Bicycle Therapeutics PLC

-22.45%

Shares1.6M

Event2026-03-31

Filed2026-05-14

WHWK

Whitehawk Therapeutics Inc

0.00%

Shares2.1M

Event2026-03-31

Filed2026-05-14

Tenax Therapeutics Inc

0.00%

Shares427.1K

Event2026-03-31

Filed2026-05-14

vTv Therapeutics Inc

0.00%

Shares163.0K

Event2026-03-31

Filed2026-05-14

DDOG

Datadog Inc

49.07%

Shares54.3K

Event2026-03-31

Filed2026-05-14

FROG

Jfrog Ltd

37.60%

Shares128.8K

Event2026-03-31

Filed2026-05-14

Dynatrace Inc

30.18%

Shares150.0K

Event2026-03-31

Filed2026-05-14

Workiva Inc

16.91%

Shares92.5K

Event2026-03-31

Filed2026-05-14

ABSI

Absci Corp

New

Shares1.8M

Event2026-03-31

Filed2026-05-14

IVVD

Invivyd Inc

0.00%

Shares4.0M

Event2026-03-31

Filed2026-05-14

Satellos Bioscience Inc

New

Shares892.1K

Event2026-03-31

Filed2026-05-14

IONQ

IONQ Inc

0.00%

Shares170.0K

Event2026-03-31

Filed2026-05-14

Broadcom Inc

114.29%

Shares15.0K

Event2026-03-31

Filed2026-05-14

Agomab Therapeutics NV

New

Shares411.3K

Event2026-03-31

Filed2026-05-14

CLBT

Cellebrite DI Ltd

107.70%

Shares311.5K

Event2026-03-31

Filed2026-05-14

SEER

Seer Inc

-38.53%

Shares2.5M

Event2026-03-31

Filed2026-05-14

KRRO

Korro Bio Inc

0.00%

Shares347.7K

Event2026-03-31

Filed2026-05-14

AGEN

Agenus Inc

0.00%

Shares1.1M

Event2026-03-31

Filed2026-05-14

FHTX

Foghorn Therapeutics Inc

0.00%

Shares720.7K

Event2026-03-31

Filed2026-05-14

Forgent Power Solutions, Inc

New

Shares100.0K

Event2026-03-31

Filed2026-05-14

KLRS

Kalaris Therapeutics Inc

0.00%

Shares435.8K

Event2026-03-31

Filed2026-05-14

GTLB

GitLab Inc

1.01%

Shares100.0K

Event2026-03-31

Filed2026-05-14

Micron Technology Inc

New

Shares6.0K

Event2026-03-31

Filed2026-05-14

MNDY

monday.com Ltd

47.06%

Shares25.0K

Event2026-03-31

Filed2026-05-14

GOSS

Gossamer Bio Inc

0.00%

Shares5.2M

Event2026-03-31

Filed2026-05-14

Amer Sports Inc

New

Shares50.0K

Event2026-03-31

Filed2026-05-14

BEKE

KE Holdings Inc

-31.03%

Shares100.0K

Event2026-03-31

Filed2026-05-14

IREN

IREN Ltd

0.00%

Shares43.1K

Event2026-03-31

Filed2026-05-14

RANI

Rani Therapeutics Holdings Inc

0.00%

Shares2.0M

Event2026-03-31

Filed2026-05-14

Aeva Technologies Inc

New

Shares110.0K

Event2026-03-31

Filed2026-05-14

Medline Inc

-66.67%

Shares25.0K

Event2026-03-31

Filed2026-05-14

FIG

Figma Inc

100.00%

Shares50.0K

Event2026-03-31

Filed2026-05-14

PRMB

Primo Brands Corp

-33.33%

Shares50.0K

Event2026-03-31

Filed2026-05-14

Nu Holdings Ltd.

New

Shares25.0K

Event2026-03-31

Filed2026-05-14

Call Option Holdings

No call option holdings data available

Put Option Holdings

No put option holdings data available