Form 4 Filing for Jason A. Keyes

On May 21, 2026, Jason A. Keyes, a director at ACTUATE THERAPEUTICS, INC., acquired 15,000 stock options for common stock. These options have an exercise price of $2.42 and expire on May 21, 2036. The options will vest in full on the anniversary of the grant date. Following this transaction, Mr. Keyes holds 15,000 shares of common stock underlying these options. The filing was signed by Paul Lytle as Attorney-in-Fact on May 22, 2026.