Opaleye Management Inc. Acquires 5.3% Stake in Rezolute, Inc.

Opaleye Management Inc., along with its affiliates Opaleye, L.P. and James Silverman, has reported acquiring beneficial ownership of 4,912,900 shares of Rezolute, Inc. common stock. This acquisition represents 5.30% of the outstanding shares, based on a total of 92,727,532 shares reported as of November 4, 2025. The filing, designated as a SCHEDULE 13G, indicates that the shares were acquired in the ordinary course of business and not with the purpose of influencing the control of the issuer. James Silverman, through his control of Opaleye Management Inc. and as an individual, exercises voting and dispositive power over these shares. This filing was made on December 19, 2025, with the event date of the statement being December 12, 2025.