Sponsored

The Analysis of Opaleye Management Inc.'s Holdings & P&L

Currently, Opaleye Management Inc. holds 55 types of securities in its portfolio with a total value $774.5M. In the most recent quarter, they have increased their positions in HROW (+2.8M shares, valued at $99.9M), LQDA (+2.5M shares, valued at $88.8M), ETON (+2.9M shares, valued at $70.6M); initiated new positions in HROW (+2.8M shares, valued at $99.9M), LQDA (+2.5M shares, valued at $88.8M), ETON (+2.9M shares, valued at $70.6M).

1M P&L

+62.6M+8.18%

3M P&L

+85.8M+11.57%

HY P&L

+104.4M+14.42%

P&L figures are estimated based on reported 13F stock holdings and market price changes. They are approximations and may not reflect actual fund performance. Stock split events may also affect the accuracy of these calculations, and we cannot guarantee that all splits have been fully accounted for.

Top Holding Treemap

Top Industries by Value

1Biotechnology521.4M

70.8%

2Drug Manufacturers - Specialty & Generic175.0M

23.8%

3Medical Devices36.5M

5.0%

Top Industries by Stock Count

1Biotechnology42 stocks

85.7%

2Medical Devices3 stocks

6.1%

3Drug Manufacturers - Specialty & Generic3 stocks

6.1%

Sponsored

Stock Holdings

TickerCompany NameSharesShares △%Event DateReport DateHistory

HROW HARROW INC2.8M sharesnew addition2026-03-312026-05-15

LQDA LIQUIDIA CORPORATION2.5M sharesnew addition2026-03-312026-05-15

ETON ETON PHARMACEUTICALS INC2.9M sharesnew addition2026-03-312026-05-15

SLGL SOL-GEL TECHNOLOGIES LTD500.0K sharesnew addition2026-03-312026-05-15

RYTM RHYTHM PHARMACEUTICALS INC123.0K sharesnew addition2026-03-312026-05-15

APGE APOGEE THERAPEUTICS INC390.0K sharesnew addition2026-03-312026-05-15

IRON DISC MEDICINE INC421.0K sharesnew addition2026-03-312026-05-15

URGN UROGEN PHARMA LTD1.4M sharesnew addition2026-03-312026-05-15

Sponsored

CRESCENT BIOPHARMA INC. CRESCENT BIOPHARMA INC.1.3M sharesnew addition2026-03-312026-05-15

STOK STOKE THERAPEUTICS INC700.0K sharesnew addition2026-03-312026-05-15

CATX PERSPECTIVE THERAPEUTICS INC4.7M sharesnew addition2026-03-312026-05-15

RZLT REZOLUTE INC6.3M sharesnew addition2026-03-312026-05-15

MGTX MEIRAGTX HLDGS PLC2.1M sharesnew addition2026-03-312026-05-15

TGTX TG THERAPEUTICS INC535.0K sharesnew addition2026-03-312026-05-15

SNWV SANUWAVE HEALTH INC981.3K sharesnew addition2026-03-312026-05-15

EWTX EDGEWISE THERAPEUTICS INC500.0K sharesnew addition2026-03-312026-05-15

Sponsored

KTTA 2.6M shares205.20%2026-05-212026-05-22

ACOG ALPHA COGNITION INC2.6M sharesnew addition2026-03-312026-05-15

ANNX ANNEXON INC2.3M sharesnew addition2026-03-312026-05-15

ALMS ALUMIS INC550.0K sharesnew addition2026-03-312026-05-15

CDXS CODEXIS INC6.8M sharesnew addition2026-03-312026-05-15

PTGX PROTAGONIST THERAPEUTICS INC100.0K sharesnew addition2026-03-312026-05-15

RVMD REVOLUTION MEDICINES INC100.0K sharesnew addition2026-03-312026-05-15

XOMA XOMA ROYALTY CORPORATION300.0K sharesnew addition2026-03-312026-05-15

Sponsored

QTTB Q32 BIO INC1.3M sharesnew addition2026-03-312026-05-15

MBX MBX BIOSCIENCES INC260.0K sharesnew addition2026-03-312026-05-15

RLMD RELMADA THERAPEUTICS INC935.0K sharesnew addition2026-03-312026-05-15

CGON CG ONCOLOGY INC94.8K sharesnew addition2026-03-312026-05-15

JBIO JADE BIOSCIENCES INC427.6K sharesnew addition2026-03-312026-05-15

OCUL OCULAR THERAPEUTIX INC600.0K sharesnew addition2026-03-312026-05-15

ASSERTIO HOLDINGS INC ASSERTIO HOLDINGS INC265.7K sharesnew addition2026-03-312026-05-15

EDIT EDITAS MEDICINE INC1.9M sharesnew addition2026-03-312026-05-15

Sponsored

SUTRO BIOPHARMA INC SUTRO BIOPHARMA INC190.7K sharesnew addition2026-03-312026-05-15

DERM JOURNEY MED CORP960.0K sharesnew addition2026-03-312026-05-15

VYGR VOYAGER THERAPEUTICS INC1.1M sharesnew addition2026-03-312026-05-15

TRVI TREVI THERAPEUTICS INC345.1K sharesnew addition2026-03-312026-05-15

TECX TECTONIC THERAPEUTIC INC123.0K sharesnew addition2026-03-312026-05-15

CABA CABALETTA BIO INC1.4M sharesnew addition2026-03-312026-05-15

BDSX BIODESIX INC238.0K sharesnew addition2026-03-312026-05-15

RCKT ROCKET PHARMACEUTICALS INC955.0K sharesnew addition2026-03-312026-05-15

Sponsored

ZNTL ZENTALIS PHARMACEUTICALS INC1.4M sharesnew addition2026-03-312026-05-15

NTLA INTELLIA THERAPEUTICS INC245.0K sharesnew addition2026-03-312026-05-15

FORTRESS BIOTECH INC FORTRESS BIOTECH INC1.0M sharesnew addition2026-03-312026-05-15

IRD OPUS GENETICS INC1.1M sharesnew addition2026-03-312026-05-15

RIGL RIGEL PHARMACEUTICALS INC70.0K sharesnew addition2026-03-312026-05-15

AVIR ATEA PHARMACEUTICALS INC322.6K sharesnew addition2026-03-312026-05-15

LYEL LYELL IMMUNOPHARMA INC79.1K sharesnew addition2026-03-312026-05-15

ENTA ENANTA PHARMACEUTICALS INC125.0K sharesnew addition2026-03-312026-05-15

Sponsored

NXTC NEXTCURE INC141.2K sharesnew addition2026-03-312026-05-15

FDMT 4D MOLECULAR THERAPEUTICS IN112.3K sharesnew addition2026-03-312026-05-15

PERSPECTIVE THERAPEUTICS INC PERSPECTIVE THERAPEUTICS INC200.0K sharesnew addition2026-03-312026-05-15

PLX PROTALIX BIOTHERAPEUTICS INC340.0K sharesnew addition2026-03-312026-05-15

BRIDGEBIO ONCOLOGY THERAPEUT BRIDGEBIO ONCOLOGY THERAPEUT53.3K sharesnew addition2026-03-312026-05-15

LBRX LB PHARMACEUTICALS INC14.5K sharesnew addition2026-03-312026-05-15

ADGM ADAGIO MED HLDGS INC18.4K sharesnew addition2026-03-312026-05-15

HROW

HARROW INC

New

Shares2.8M

Event2026-03-31

Filed2026-05-15

LQDA

LIQUIDIA CORPORATION

New

Shares2.5M

Event2026-03-31

Filed2026-05-15

ETON

ETON PHARMACEUTICALS INC

New

Shares2.9M

Event2026-03-31

Filed2026-05-15

SLGL

SOL-GEL TECHNOLOGIES LTD

New

Shares500.0K

Event2026-03-31

Filed2026-05-15

RYTM

RHYTHM PHARMACEUTICALS INC

New

Shares123.0K

Event2026-03-31

Filed2026-05-15

APGE

APOGEE THERAPEUTICS INC

New

Shares390.0K

Event2026-03-31

Filed2026-05-15

IRON

DISC MEDICINE INC

New

Shares421.0K

Event2026-03-31

Filed2026-05-15

URGN

UROGEN PHARMA LTD

New

Shares1.4M

Event2026-03-31

Filed2026-05-15

CRESCENT BIOPHARMA INC.

New

Shares1.3M

Event2026-03-31

Filed2026-05-15

STOK

STOKE THERAPEUTICS INC

New

Shares700.0K

Event2026-03-31

Filed2026-05-15

CATX

PERSPECTIVE THERAPEUTICS INC

New

Shares4.7M

Event2026-03-31

Filed2026-05-15

RZLT

REZOLUTE INC

New

Shares6.3M

Event2026-03-31

Filed2026-05-15

MGTX

MEIRAGTX HLDGS PLC

New

Shares2.1M

Event2026-03-31

Filed2026-05-15

TGTX

TG THERAPEUTICS INC

New

Shares535.0K

Event2026-03-31

Filed2026-05-15

SNWV

SANUWAVE HEALTH INC

New

Shares981.3K

Event2026-03-31

Filed2026-05-15

EWTX

EDGEWISE THERAPEUTICS INC

New

Shares500.0K

Event2026-03-31

Filed2026-05-15

KTTA

205.20%

Shares2.6M

Event2026-05-21

Filed2026-05-22

ACOG

ALPHA COGNITION INC

New

Shares2.6M

Event2026-03-31

Filed2026-05-15

ANNX

ANNEXON INC

New

Shares2.3M

Event2026-03-31

Filed2026-05-15

ALMS

ALUMIS INC

New

Shares550.0K

Event2026-03-31

Filed2026-05-15

CDXS

CODEXIS INC

New

Shares6.8M

Event2026-03-31

Filed2026-05-15

PTGX

PROTAGONIST THERAPEUTICS INC

New

Shares100.0K

Event2026-03-31

Filed2026-05-15

RVMD

REVOLUTION MEDICINES INC

New

Shares100.0K

Event2026-03-31

Filed2026-05-15

XOMA

XOMA ROYALTY CORPORATION

New

Shares300.0K

Event2026-03-31

Filed2026-05-15

QTTB

Q32 BIO INC

New

Shares1.3M

Event2026-03-31

Filed2026-05-15

MBX

MBX BIOSCIENCES INC

New

Shares260.0K

Event2026-03-31

Filed2026-05-15

RLMD

RELMADA THERAPEUTICS INC

New

Shares935.0K

Event2026-03-31

Filed2026-05-15

CGON

CG ONCOLOGY INC

New

Shares94.8K

Event2026-03-31

Filed2026-05-15

JBIO

JADE BIOSCIENCES INC

New

Shares427.6K

Event2026-03-31

Filed2026-05-15

OCUL

OCULAR THERAPEUTIX INC

New

Shares600.0K

Event2026-03-31

Filed2026-05-15

ASSERTIO HOLDINGS INC

New

Shares265.7K

Event2026-03-31

Filed2026-05-15

EDIT

EDITAS MEDICINE INC

New

Shares1.9M

Event2026-03-31

Filed2026-05-15

SUTRO BIOPHARMA INC

New

Shares190.7K

Event2026-03-31

Filed2026-05-15

DERM

JOURNEY MED CORP

New

Shares960.0K

Event2026-03-31

Filed2026-05-15

VYGR

VOYAGER THERAPEUTICS INC

New

Shares1.1M

Event2026-03-31

Filed2026-05-15

TRVI

TREVI THERAPEUTICS INC

New

Shares345.1K

Event2026-03-31

Filed2026-05-15

TECX

TECTONIC THERAPEUTIC INC

New

Shares123.0K

Event2026-03-31

Filed2026-05-15

CABA

CABALETTA BIO INC

New

Shares1.4M

Event2026-03-31

Filed2026-05-15

BDSX

BIODESIX INC

New

Shares238.0K

Event2026-03-31

Filed2026-05-15

RCKT

ROCKET PHARMACEUTICALS INC

New

Shares955.0K

Event2026-03-31

Filed2026-05-15

ZNTL

ZENTALIS PHARMACEUTICALS INC

New

Shares1.4M

Event2026-03-31

Filed2026-05-15

NTLA

INTELLIA THERAPEUTICS INC

New

Shares245.0K

Event2026-03-31

Filed2026-05-15

FORTRESS BIOTECH INC

New

Shares1.0M

Event2026-03-31

Filed2026-05-15

IRD

OPUS GENETICS INC

New

Shares1.1M

Event2026-03-31

Filed2026-05-15

RIGL

RIGEL PHARMACEUTICALS INC

New

Shares70.0K

Event2026-03-31

Filed2026-05-15

AVIR

ATEA PHARMACEUTICALS INC

New

Shares322.6K

Event2026-03-31

Filed2026-05-15

LYEL

LYELL IMMUNOPHARMA INC

New

Shares79.1K

Event2026-03-31

Filed2026-05-15

ENTA

ENANTA PHARMACEUTICALS INC

New

Shares125.0K

Event2026-03-31

Filed2026-05-15

NXTC

NEXTCURE INC

New

Shares141.2K

Event2026-03-31

Filed2026-05-15

FDMT

4D MOLECULAR THERAPEUTICS IN

New

Shares112.3K

Event2026-03-31

Filed2026-05-15

PERSPECTIVE THERAPEUTICS INC

New

Shares200.0K

Event2026-03-31

Filed2026-05-15

PLX

PROTALIX BIOTHERAPEUTICS INC

New

Shares340.0K

Event2026-03-31

Filed2026-05-15

BRIDGEBIO ONCOLOGY THERAPEUT

New

Shares53.3K

Event2026-03-31

Filed2026-05-15

LBRX

LB PHARMACEUTICALS INC

New

Shares14.5K

Event2026-03-31

Filed2026-05-15

ADGM

ADAGIO MED HLDGS INC

New

Shares18.4K

Event2026-03-31

Filed2026-05-15

Call Option Holdings

No call option holdings data available

Put Option Holdings

No put option holdings data available