Officer and Director Transactions

Christophe Pierre Weber, President and CEO of TAKEDA PHARMACEUTICAL CO LTD, reported transactions on April 27, 2026. Weber acquired 78,900 Ordinary Shares with a post-transaction total of 1,014,200 shares. Additionally, 165,370 American Depositary Shares (ADS) were acquired, resulting in 418,803 ADSs held post-transaction. A Tax Obligation Award transaction involved 78,978 units, with 125,345 units held afterward. These transactions are related to restricted stock units (RSUs) granted on July 1, 2023, which vest based on performance metrics and are settled in Ordinary Shares or ADSs. The Tax Obligation Award is economically equivalent to Ordinary Shares, primarily for covering tax obligations.