Power of Attorney for Septerna, Inc. Director

The filing is a Limited Power of Attorney document for Keith Gottesdiener, a director of Septerna, Inc. The document appoints Jeffrey Finer, Elizabeth Bhatt, Gil M. Labrucherie, and Ran Xiao as attorneys-in-fact to act on Gottesdiener's behalf in matters related to SEC filings. These include executing Form ID, Form 3, Form 4, Form 5, Schedules 13D and 13G, and any amendments to these forms. The attorneys-in-fact are authorized to perform any necessary actions to complete and file these forms with the SEC and other relevant authorities. The Power of Attorney remains in effect until Gottesdiener is no longer required to file such forms or until revoked in writing. The document also includes an indemnification clause protecting the attorneys-in-fact and the company from any liabilities arising from false or misleading information provided by Gottesdiener.