Deborah Miller's Stock Option Exercise and Sale Plan

Deborah Miller, an officer of Nuvalent Inc., has filed a Form 144 to report her plan to sell 54,000 shares of common stock acquired through the exercise of stock options. The options were exercised on October 15, 2025, and the shares are to be sold on the same date. The aggregate market value of the shares is approximately $4,571,640. The sale will be facilitated by Morgan Stanley Smith Barney LLC Executive Financial Services. The plan was adopted on November 18, 2024. There are no securities sold in the past three months to report.