NuCana plc Announces ADS Ratio Change

SEC Filing 6-K (0001193125-25-171672)

NuCana plc (NASDAQ: NCNA) has announced a change in the ratio of its American Depositary Shares (ADSs) to its ordinary shares, effective August 11, 2025. The new ratio will be one ADS representing 5,000 ordinary shares, compared to the previous ratio of one ADS representing 25 ordinary shares. This change is equivalent to a one-for-two-hundred reverse ADS split and will not affect the proportional equity interest of ADS holders. The adjustment aims to support liquidity in the company's ADSs and help regain compliance with Nasdaq's minimum bid price requirement. Holders of certificated ADSs will need to surrender their shares for cancellation and will receive new ADSs in exchange, while uncertificated ADSs will be automatically exchanged. The company's ADSs will continue to trade on the Nasdaq Capital Market under the ticker symbol 'NCNA.'