Form 4 Filing for Brian S. Tyler

This filing details transactions made by Brian S. Tyler, CEO of McKesson Corp. On May 23, 2026, Tyler acquired 4,579 shares of Common Stock through the vesting of Restricted Stock Units (RSUs) with no cost. Simultaneously, 4,579 RSUs were disposed of. In a separate transaction on the same date, 1,831 shares of Common Stock were disposed of at a price of $766.08 per share, to cover applicable taxes related to the RSU vesting. Following these transactions, Tyler directly holds 27,774 shares of Common Stock. Additionally, the filing notes indirect ownership of 215.7888 shares of Common Stock held through the McKesson Corporation 401(k) Retirement Savings Plan.