Form 4 Filing for Opus Genetics, Inc.

Joseph K. Schachle, Chief Operating Officer of Opus Genetics, Inc., reported a sale of 4,644 shares of Common Stock on July 23, 2026. The shares were sold at a price of $2.94 per share, resulting in a post-transaction ownership of 291,440 shares. This sale was executed automatically to cover tax withholding obligations related to a restricted stock units award vesting and settlement event, and does not represent a discretionary trade by Mr. Schachle. The filing was signed by Amy Rabourn, by Power of Attorney, on July 27, 2026.