Form 4 Filing for Eric Swayze

This filing details a transaction by Eric Swayze, EVP Research at IONIS PHARMACEUTICALS INC, on June 25, 2026. Swayze sold 10,602 shares of Common Stock under a Rule 10b5-1 Trading Plan, at a weighted average price of $79.1824 per share. The sales occurred in multiple transactions with prices ranging from $79.00 to $79.46. Following this transaction, Swayze directly owns 21,759 shares. Additionally, he indirectly owns 318 shares through his son. The filing was signed by Patrick R. O'Neil as attorney-in-fact for Eric Swayze.