Form 4 Filing for Brett P. Monia

On June 24, 25, and 26, 2026, Brett P. Monia, CEO and Director of Ionis Pharmaceuticals Inc., executed several transactions involving the company's Common Stock. Monia acquired a total of 85,637 shares through the exercise of stock options at prices ranging from $32.60 to $56.78. Concurrently, Monia disposed of 85,637 shares of Common Stock. These sales occurred under a Rule 10b5-1 Trading Plan adopted on December 8, 2025. The sales were executed at various prices, with weighted average prices reported for each transaction date. Specifically, on June 24, shares were sold at a weighted average of $78.4128; on June 25, at $78.49; and on June 26, at $80.59. Following these transactions, Monia's post-transaction shares in the company amount to 245,571.