Officer and Director Stock Transactions

David Michael Clark, Chief People Officer of AMICUS THERAPEUTICS, INC., reported the disposition of 221,811 shares of Common Stock on April 27, 2026, at a price of $14.50 per share. This transaction, along with the cancellation and conversion of various stock options into cash payments, occurred in connection with the acquisition of the Issuer by BioMarin Pharmaceutical Inc. All reported stock options were fully vested prior to or at the time of the merger. Following these transactions, Mr. Clark no longer holds any direct shares or stock options in the company. The total value of the disposed shares was $3,216,259.50. The stock options, totaling 671,820 shares, were converted into cash payments based on the difference between $14.50 and their respective exercise prices, as detailed in footnote 2.