Form 4 Filing for Richard William Scalzo

Richard William Scalzo, Chief Financial Officer of CRESCENT BIOPHARMA, INC., reported a disposition of 1112 ordinary shares on June 22, 2026. The shares were sold at an average price of $17.99 per share, with individual transactions ranging from $16.88 to $18.86. This sale was conducted under a Rule 10b5-1 instruction to cover tax withholding obligations related to the settlement of restricted stock units granted on December 15, 2025. The sale was executed to cover taxes in connection with the vesting of these units. Following the transaction, Mr. Scalzo owns 20,298 shares.