Insider Transaction Report for Skynner Michael

This filing details transactions made by Skynner Michael, Chief Scientific Officer of BICYCLE THERAPEUTICS PLC. On April 2, 2026, 1879 ordinary shares were disposed of at a weighted average price of $4.91, with prices ranging from $4.88 to $4.98. Following this transaction, 160,087 shares remained. On April 6, 2026, an additional 525 ordinary shares were disposed of at a weighted average price of $5.05, with prices ranging from $5.03 to $5.05. The total shares owned after this second transaction were 159,562. These sales were mandated to cover statutory tax withholding obligations in connection with the vesting and settlement of RSUs, as per the reporting person's award agreement. This does not represent discretionary sales.