Form 4 Filing for Michael Charles Ferguson Hannay

Michael Charles Ferguson Hannay, Chief Production & Supply Chain Officer at BICYCLE THERAPEUTICS PLC, reported the sale of 1572 ordinary shares on October 2, 2026, for $3.47 per share, and 242 ordinary shares on October 5, 2026, for $3.57 per share. These transactions were mandated to cover statutory tax withholding obligations related to Restricted Stock Units (RSUs) vesting, as per the award agreement. The sales were executed through a "sell to cover" mechanism, and not discretionary. Following these transactions, Mr. Hannay holds 92,803 shares after the first sale and 92,561 shares after the second sale. The sales on October 2nd occurred at a weighted average price, with individual transactions ranging from $3.41 to $3.525. The sales on October 5th also occurred at a weighted average price, with transactions ranging from $3.56 to $3.57.