Form 4 Filing for BICYCLE THERAPEUTICS PLC

This filing details transactions by Kevin Lee, Chief Executive Officer of BICYCLE THERAPEUTICS PLC (BCYC). On April 2, 2026, Lee sold 5,967 ordinary shares at a weighted average price of $4.91, with prices ranging from $4.88 to $4.98. Following this transaction, he owned 613,029 shares. On April 6, 2026, Lee sold an additional 1,716 ordinary shares at a weighted average price of $5.05, with prices ranging from $5.03 to $5.05. This left him with 611,313 shares. Footnote 1 indicates these sales were mandated to cover statutory tax withholding obligations upon the vesting of RSUs, as per his award agreement, and are not discretionary. Footnotes 2 and 3 provide details on the weighted average pricing for the transactions.