Form 4 Filing for BICYCLE THERAPEUTICS PLC

Robert Charles Swanton, a director at BICYCLE THERAPEUTICS PLC, reported the sale of 3,431 ordinary shares on October 2, 2026. The sale was executed at a weighted average price of $3.47 per share, with individual transactions ranging from $3.41 to $3.525. This transaction was mandated by the reporting person's award agreement to cover statutory tax withholding obligations upon the vesting and settlement of RSUs, and does not represent a discretionary sale. Following this transaction, Swanton holds 15,782 shares. The sale was conducted through a "sell to cover" transaction.