Form 4 Filing for BICYCLE THERAPEUTICS PLC

This filing details transactions by Thompson Travis Alvin, Chief Financial Officer of BICYCLE THERAPEUTICS PLC. On April 2, 2026, 799 ordinary shares were sold at a weighted average price of $4.91, with individual sales ranging from $4.88 to $4.98. This sale was to cover statutory tax withholding obligations, as mandated by the award agreement, and does not represent a discretionary sale. Following this transaction, 65,466 shares remained. On April 6, 2026, an additional 102 ordinary shares were sold at $5.05 per share, reducing the total shares held to 65,364. These sales were also related to covering tax withholding requirements. The reporting person has undertaken to provide further details on the specific prices if requested.