Form 4 Filing for BICYCLE THERAPEUTICS PLC

Jennifer Scott Perry, Chief Operating Officer of BICYCLE THERAPEUTICS PLC, reported a sale of 1094 ordinary shares on October 2, 2026, for $3.47 per share. This transaction was part of a Rule 10b5-1 trading plan and was mandated to cover statutory tax withholding obligations. On October 5, 2026, two additional sales were reported: 80 shares at a weighted average price of $3.56 and 326 shares at $3.78 per share. These transactions also appear to be related to tax obligations and/or trading plans. Following these transactions, Ms. Perry