Form 4 Filing for BICYCLE THERAPEUTICS PLC

This filing details transactions by Thompson Travis Alvin, Chief Financial Officer of BICYCLE THERAPEUTICS PLC. On July 2, 2026, 819 ordinary shares were sold at a weighted average price of $4.27 per share, with prices ranging from $4.26 to $4.29. Following this transaction, 64,545 shares remained. On July 6, 2026, an additional 104 ordinary shares were sold at a weighted average price of $4.31 per share, with prices ranging from $4.30 to $4.31. After this sale, 64,441 shares remained. The sales were made to cover statutory tax withholding obligations related to Restricted Stock Units (RSUs) vesting and settlement, as mandated by the reporting person's award agreement. This is a mandatory "sell to cover" transaction and not a discretionary sale.