Form 4 Filing for BICYCLE THERAPEUTICS PLC

This filing details transactions made by Skynner Michael, Chief Scientific Officer of BICYCLE THERAPEUTICS PLC. On July 2, 2026, 1859 Ordinary Shares were disposed of at a weighted average price of $4.27, with individual sales ranging from $4.26 to $4.29. Following this transaction, 157703 shares remained. On July 6, 2026, an additional 532 Ordinary Shares were disposed of at a weighted average price of $4.31, with sales ranging from $4.30 to $4.31. The post-transaction share count after this sale was 157171. These sales were mandated to cover statutory tax withholding obligations upon the vesting of RSUs, as per the reporting person's award agreement, and do not represent discretionary sales. The reporting person has undertaken to provide detailed information on specific prices upon request.