Bicycle Therapeutics COO Jennifer Scott Perry's Stock Sales Under 10b5-1 Plan

This Form 4 filing discloses three separate stock sale transactions by Jennifer Scott Perry, Chief Operating Officer of Bicycle Therapeutics PLC. On July 2, 2026, Perry sold 1,036 ordinary shares at a weighted average price of $4.27 per share to cover tax withholding obligations related to RSU vesting. On July 6, 2026, she sold an additional 43 shares at $4.31 per share for the same tax withholding purpose. Also on July 6, she sold 333 shares at $4.34 per share pursuant to a Rule 10b5-1 trading plan adopted on March 27, 2025. Following these transactions, Perry's total holdings decreased to 91,052 ordinary shares. The sales were executed at prices ranging from $4.26 to $4.34 per share, with the 10b5-1 plan transaction representing a pre-arranged trading strategy.