Form 6-K Filing by AstraZeneca PLC

This Form 6-K filing by AstraZeneca PLC reports the total voting rights as of August 31, 2026. The issued share capital with voting rights is 1,551,043,461 ordinary shares of US$0.25 each. There are no shares held in Treasury. Therefore, the total number of voting rights is 1,551,043,461. This figure serves as the denominator for shareholders to determine notification requirements regarding their interests in AstraZeneca PLC under the UK Financial Conduct Authority's Disclosure and Transparency Rules. AstraZeneca is a global, science-led biopharmaceutical company focused on discovery, development, and commercialization of prescription medicines in Oncology, Rare Disease, and BioPharmaceuticals. The company's medicines are sold in over 125 countries.