Director/PDMR Shareholding Notification

AstraZeneca PLC announced on December 22, 2025, a shareholding transaction by Nazneen Rahman, a Non-Executive Director. On December 18, 2025, Ms. Rahman sold 297 ordinary shares of AstraZeneca PLC at a price of £134.96 per share. This notification is in accordance with the EU Market Abuse Regulation, as incorporated into UK law. The filing includes details of the issuer, the person discharging managerial responsibilities, and the transaction itself, including the instrument description, nature of transaction, price, volume, and date.