Report of Executive Officer Transaction

On June 9, 2026, Tabuteau Herriot, Chief Executive Officer of Axsome Therapeutics, Inc. (AXSM), exercised stock options for 49,670 shares of Common Stock at a price of $0.00 per share, under a pre-approved 10b5-1 plan. These options were set to expire due to reaching their 10-year limit. The exercise was necessary to facilitate the subsequent sale of these shares. On the same day, Herriot sold these 49,670 shares at a weighted average price of $241.01 per share, with prices ranging from $236.11 to $244.13. Following these transactions, Herriot directly owns 7,229 shares of Common Stock. Additionally, there is an indirect ownership of 7,344,500 shares, held by an entity where Herriot has voting and dispositive power.