Sarah Gheuens' Transactions in Agios Pharmaceuticals, Inc. Common Stock

On October 27, 2025, Sarah Gheuens, Chief Medical Officer of Agios Pharmaceuticals, Inc., engaged in several transactions involving the company's common stock. She acquired 3,302 shares at $25.01 per share and subsequently disposed of the same number of shares at a weighted average price of $43.92. The sale was executed under a Rule 10b5-1 trading plan. Additionally, she disposed of 3,302 stock options (right to buy) with an exercise price of $25.01 per share. Following these transactions, Gheuens owns 61,727 shares of common stock and 28,784 stock options. The transactions were reported in a Form 4 filing with the SEC.