Form 4 Filing for Smith Cynthia

This filing details transactions by Cynthia Smith, a director at Agios Pharmaceuticals, Inc. On June 18, 2026, Smith acquired 2,816 shares of common stock through the disposition of restricted stock units. Additionally, she was granted 2,927 restricted stock units and 14,950 stock options, all with a \$0.00 price per share. The restricted stock units granted on June 18, 2025, vest on June 18, 2026, while those granted on June 18, 2026, vest on June 18, 2027. The stock options granted on June 18, 2026, vest on June 18, 2027. Following these transactions, Smith holds 15,230 shares of common stock and has 0 vested restricted stock units.