Form 4 Filing for Agios Pharmaceuticals, Inc. - Officer Transaction

This filing details transactions made by James William Burns, Chief Legal Officer of Agios Pharmaceuticals, Inc. On April 2, 2026, Mr. Burns acquired 8,500 shares of common stock through the vesting of performance share units (PSUs), with a reported transaction value of $0. These PSUs were granted on March 1, 2024, and vested upon the achievement of a specified regulatory milestone. Concurrently, Mr. Burns disposed of 3,280 shares of common stock at a price of $34.71 per share to cover tax withholding obligations related to the PSU vesting. This disposal was executed under automatic sale instructions consistent with Rule 10b5-1(c). Following these transactions, Mr. Burns holds 49,306 shares of common stock directly.