AGIOS PHARMACEUTICALS, INC. - Officer Transaction Report

Tsveta Milanova, Chief Commercial Officer of AGIOS PHARMACEUTICALS, INC., reported a series of transactions on April 2, 2026. Milanova acquired 8,500 shares of common stock through the vesting of performance share units (PSUs). These PSUs, granted on March 1, 2024, vested upon the achievement of a specified regulatory milestone. Concurrently, 3,262 shares were sold at $34.71 per share to cover tax withholding obligations related to the PSU vesting. These sales were executed under automatic sale instructions consistent with Rule 10b5-1(c). Following these transactions, Milanova holds 46,829 shares of common stock directly.