Form 4 Filing by Opaleye Management Inc. for Alpha Cognition Inc.

Opaleye Management Inc., a 10% owner, reported transactions involving Alpha Cognition Inc. common stock. On May 15, 2026, the company acquired 16,648 shares at a weighted average price of $5.83, bringing the post-transaction total to 2,488,598 shares. This acquisition was made through Opaleye, L.P. On May 18, 2026, an additional 17,395 shares were acquired at a weighted average price of $5.69, resulting in 2,505,993 shares held post-transaction, also through Opaleye, L.P. Additionally, 90,000 shares are held via a separately managed account, for which Opaleye may be deemed beneficial owner. Opaleye Management Inc. disclaims beneficial ownership beyond its pecuniary interest.