Form 4 Filing by Opaleye Management Inc. for Alpha Cognition Inc.

Opaleye Management Inc., a ten percent owner, reported transactions involving Alpha Cognition Inc. common stock. On March 27, 2026, 10,000 shares were acquired at a weighted average price of $5.0792 per share, bringing the post-transaction holdings to 2,470,000 shares. This acquisition was made through Opaleye, L.P. On March 30, 2026, an additional 1,850 shares were acquired at $4.9873 per share, resulting in 2,471,850 shares held. A portion of the shares, 90,000, are held through a separately managed account. Opaleye Management Inc. disclaims beneficial ownership except to the extent of its pecuniary interest.