Form 4 Filing by Opaleye Management Inc. for Alpha Cognition Inc.

This filing details recent transactions by Opaleye Management Inc., a 10% owner of Alpha Cognition Inc. (ACOG). On June 25, 2026, Opaleye acquired 197 shares of common stock at a weighted average price of $6.50 per share, increasing their holdings to 2,652,771 shares. On June 26, 2026, a further 152,336 shares were acquired at a weighted average price of $6.4017, bringing the total post-transaction shares to 2,805,107. These transactions were made through Opaleye, L.P. and a separately managed account. Opaleye Management Inc. disclaims beneficial ownership beyond its pecuniary interest. The filing also notes 90,000 shares owned by a managed account.