The Analysis of SPHERA FUNDS MANAGEMENT LTD.'s Holdings

Currently, SPHERA FUNDS MANAGEMENT LTD. holds 101 types of securities in its portfolio with a total value $421.6M. In the most recent quarter, they have increased their positions in NICE (+157.4K shares, valued at $22.8M), QQQ (+23.0K shares, valued at $13.8M), RARE (+252.5K shares, valued at $7.6M); decreased their positions in SNDX (-1.2M shares, valued at $18.2M), NVMI (-31.9K shares, valued at $10.2M), MLYS (-261.1K shares, valued at $9.9M); initiated new positions in NICE (+157.4K shares, valued at $22.8M), QQQ (+23.0K shares, valued at $13.8M), CLBT (+298.9K shares, valued at $5.5M).

Top Holding Treemap

Stock Holdings

TickerCompany NameSharesShares △%Event DateReport DateHistory

TEVA TEVA PHARMACEUTICAL INDS LTD1.5M shares-7.03%2025-09-302025-11-14

NICE NICE LTD157.4K sharesnew addition2025-09-302025-11-14

TSEM TOWER SEMICONDUCTOR LTD311.8K shares17.78%2025-09-302025-11-14

NVMI NOVA LTD43.9K shares-42.12%2025-09-302025-11-14

QQQ INVESCO QQQ TR23.0K sharesnew addition2025-09-302025-11-14

BIIB BIOGEN INC82.7K shares0.00%2025-09-302025-11-14

RARE ULTRAGENYX PHARMACEUTICAL IN352.6K shares252.26%2025-09-302025-11-14

AZN ASTRAZENECA PLC135.1K shares0.00%2025-09-302025-11-14

Sponsored

SNY SANOFI SA219.5K shares0.00%2025-09-302025-11-14

CYTK CYTOKINETICS INC161.5K shares-50.56%2025-09-302025-11-14

MLYS MINERALYS THERAPEUTICS INC219.9K shares-54.28%2025-09-302025-11-14

FOLD AMICUS THERAPEUTICS INC991.1K shares0.04%2025-09-302025-11-14

LLY ELI LILLY & CO10.0K shares-13.00%2025-09-302025-11-14

JNJ JOHNSON & JOHNSON40.8K shares0.00%2025-09-302025-11-14

CDTX CIDARA THERAPEUTICS INC75.7K shares-45.11%2025-09-302025-11-14

FBRX FORTE BIOSCIENCES INC474.3K shares-4.20%2025-09-302025-11-14

Sponsored

SNDX SYNDAX PHARMACEUTICALS INC387.7K shares-75.33%2025-09-302025-11-14

TRVI TREVI THERAPEUTICS INC644.0K shares-19.50%2025-09-302025-11-14

NVO NOVO-NORDISK A S105.7K shares0.00%2025-09-302025-11-14

ABBV ABBVIE INC25.3K shares0.00%2025-09-302025-11-14

CLBT CELLEBRITE DI LTD298.9K sharesnew addition2025-09-302025-11-14

ANNX ANNEXON INC1.8M shares1.70%2025-09-302025-11-14

DYN DYNE THERAPEUTICS INC426.5K shares92.63%2025-09-302025-11-14

CLDX CELLDEX THERAPEUTICS INC NEW207.8K shares-50.48%2025-09-302025-11-14

Sponsored

SOLAREDGE TECHNOLOGIES INC SOLAREDGE TECHNOLOGIES INC4.0M sharesnew addition2025-09-302025-11-14

GSK GSK PLC122.0K shares0.00%2025-09-302025-11-14

SEDG SOLAREDGE TECHNOLOGIES INC141.0K shares10.16%2025-09-302025-11-14

ORIC ORIC PHARMACEUTICALS INC431.7K shares9.37%2025-09-302025-11-14

IMTX IMMATICS N.V583.1K shares0.00%2025-09-302025-11-14

GPCR STRUCTURE THERAPEUTICS INC173.9K shares81.31%2025-09-302025-11-14

SVRA SAVARA INC1.4M shares3.06%2025-09-302025-11-14

NVS NOVARTIS AG37.0K shares0.00%2025-09-302025-11-14

Sponsored

RAPP RAPPORT THERAPEUTICS INC157.5K sharesnew addition2025-09-302025-11-14

VRNS VARONIS SYS INC73.9K sharesnew addition2025-09-302025-11-14

IMVT IMMUNOVANT INC256.7K shares0.00%2025-09-302025-11-14

MRK MERCK & CO INC48.6K shares0.00%2025-09-302025-11-14

MAZE MAZE THERAPEUTICS INC154.3K shares-56.70%2025-09-302025-11-14

ENGN ENGENE HOLDINGS INC504.4K shares0.00%2025-09-302025-11-14

ESLT ELBIT SYS LTD6.7K shares12.33%2025-09-302025-11-14

RZLT REZOLUTE INC363.9K shares-51.57%2025-09-302025-11-14

Sponsored

ELVN ENLIVEN THERAPEUTICS INC166.8K shares29.76%2025-09-302025-11-14

MDWD MEDIWOUND LTD185.3K sharesnew addition2025-09-302025-11-14

ELDN ELEDON PHARMACEUTICALS INC1.3M shares-34.67%2025-09-302025-11-14

ACAD ACADIA PHARMACEUTICALS INC148.9K shares-14.87%2025-09-302025-11-14

PRAX PRAXIS PRECISION MEDICINES I57.9K shares-47.25%2025-09-302025-11-14

CAMT CAMTEK LTD29.0K shares-9.16%2025-09-302025-11-14

AMZN AMAZON COM INC13.8K shares-57.58%2025-09-302025-11-14

CRVS CORVUS PHARMACEUTICALS INC407.7K shares122.68%2025-09-302025-11-14

Sponsored

PHVS PHARVARIS N V119.4K shares-61.47%2025-09-302025-11-14

META META PLATFORMS INC3.9K shares-53.98%2025-09-302025-11-14

SLNO SOLENO THERAPEUTICS INC41.6K sharesnew addition2025-09-302025-11-14

RVMD REVOLUTION MEDICINES INC60.0K sharesnew addition2025-09-302025-11-14

ORA ORMAT TECHNOLOGIES INC29.0K shares-62.82%2025-09-302025-11-14

IDYA IDEAYA BIOSCIENCES INC100.0K sharesnew addition2025-09-302025-11-14

AMGN AMGEN INC9.5K shares0.00%2025-09-302025-11-14

AMD ADVANCED MICRO DEVICES INC15.5K shares87.52%2025-09-302025-11-14

Sponsored

ACOG ALPHA COGNITION INC338.8K shares-10.06%2025-09-302025-11-14

PFE PFIZER INC86.0K shares0.00%2025-09-302025-11-14

CYBN CYBIN INC370.4K shares-7.01%2025-09-302025-11-14

KURA KURA ONCOLOGY INC245.5K shares4.25%2025-09-302025-11-14

AVGO BROADCOM INC6.6K sharesnew addition2025-09-302025-11-14

CEVA CEVA INC81.1K shares65.75%2025-09-302025-11-14

BBIO BRIDGEBIO PHARMA INC40.7K shares-53.22%2025-09-302025-11-14

JANX JANUX THERAPEUTICS INC85.8K shares0.00%2025-09-302025-11-14

Sponsored

SKYE SKYE BIOSCIENCE INC478.9K shares-11.05%2025-09-302025-11-14

ATXS ASTRIA THERAPEUTICS INC251.2K shares-2.40%2025-09-302025-11-14

TECX TECTONIC THERAPEUTIC INC115.9K sharesnew addition2025-09-302025-11-14

PCVX VAXCYTE INC50.0K sharesnew addition2025-09-302025-11-14

CATX PERSPECTIVE THERAPEUTICS INC510.3K shares64.44%2025-09-302025-11-14

IMNM IMMUNOME INC147.2K sharesnew addition2025-09-302025-11-14

MIST MILESTONE PHARMACEUTICALS IN820.0K sharesnew addition2025-09-302025-11-14

JSPR JASPER THERAPEUTICS INC629.5K shares4190.57%2025-09-302025-11-14

Sponsored

QURE UNIQURE NV24.9K sharesnew addition2025-09-302025-11-14

APLS APELLIS PHARMACEUTICALS INC63.7K shares-44.33%2025-09-302025-11-14

COGT COGENT BIOSCIENCES INC98.5K shares-31.43%2025-09-302025-11-14

IBIT ISHARES BITCOIN TRUST ETF21.5K shares0.00%2025-09-302025-11-14

VTYX VENTYX BIOSCIENCES INC440.1K shares-20.82%2025-09-302025-11-14

BHVN BIOHAVEN LTD91.2K shares-37.30%2025-09-302025-11-14

BCAX BICARA THERAPEUTICS INC85.7K shares30.55%2025-09-302025-11-14

TSHA TAYSHA GENE THERAPIES INC408.1K shares-2.82%2025-09-302025-11-14

Sponsored

DAWN DAY ONE BIOPHARMACEUTICALS I175.4K shares0.00%2025-09-302025-11-14

HOWL WEREWOLF THERAPEUTICS INC626.8K shares0.00%2025-09-302025-11-14

SABS SAB BIOTHERAPEUTICS INC566.4K sharesnew addition2025-09-302025-11-14

ENPH ENPHASE ENERGY INC26.7K sharesnew addition2025-09-302025-11-14

VYGR VOYAGER THERAPEUTICS INC199.8K sharesnew addition2025-09-302025-11-14

CLYM CLIMB BIO INC434.8K shares107.23%2025-09-302025-11-14

LRMR LARIMAR THERAPEUTICS INC260.4K shares32.42%2025-09-302025-11-14

PEPG PEPGEN INC171.5K shares9.59%2025-09-302025-11-14

Sponsored

BMY BRISTOL-MYERS SQUIBB CO17.5K shares0.00%2025-09-302025-11-14

VSTM VERASTEM INC78.3K shares-52.05%2025-09-302025-11-14

ROIV ROIVANT SCIENCES LTD42.6K sharesnew addition2025-09-302025-11-14

ETNB 89BIO INC39.7K shares-80.71%2025-09-302025-11-14

MLTX MOONLAKE IMMUNOTHERAPEUTICS71.0K sharesnew addition2025-09-302025-11-14

CMMB CHEMOMAB THERAPEUTICS LTD179.4K sharesnew addition2025-09-302025-11-14

ARWR ARROWHEAD PHARMACEUTICALS IN12.5K shares-93.84%2025-09-302025-11-14

APRE APREA THERAPEUTICS INC270.0K shares0.00%2025-09-302025-11-14

Sponsored

WVE WAVE LIFE SCIENCES LTD50.0K sharesnew addition2025-09-302025-11-14

OKUR ONKURE THERAPEUTICS INC60.5K shares0.00%2025-09-302025-11-14

DSGN DESIGN THERAPEUTICS INC21.9K sharesnew addition2025-09-302025-11-14

PMN PROMIS NEUROSCIENCES INC295.2K shares-84.46%2025-09-302025-11-14

APLT APPLIED THERAPEUTICS INC50.0K shares0.00%2025-09-302025-11-14

Call Option Holdings

MRUS Call CallMERUS N V150.0K sharesnew addition2025-09-302025-11-14

CDTX Call CallCIDARA THERAPEUTICS INC100.0K sharesnew addition2025-09-302025-11-14

BBIO Call CallBRIDGEBIO PHARMA INC130.0K sharesnew addition2025-09-302025-11-14

TLT Call CallISHARES TR47.0K shares0.00%2025-09-302025-11-14

SRPT Call CallSAREPTA THERAPEUTICS INC150.0K shares0.00%2025-09-302025-11-14

PRAX Call CallPRAXIS PRECISION MEDICINES I50.0K shares-50.00%2025-09-302025-11-14

TVTX Call CallTRAVERE THERAPEUTICS INC101.8K sharesnew addition2025-09-302025-11-14

ROIV Call CallROIVANT SCIENCES LTD151.6K sharesnew addition2025-09-302025-11-14

GPCR Call CallSTRUCTURE THERAPEUTICS INC50.0K sharesnew addition2025-09-302025-11-14

TRVI Call CallTREVI THERAPEUTICS INC129.2K sharesnew addition2025-09-302025-11-14

MLTX Call CallMOONLAKE IMMUNOTHERAPEUTICS10.0K shares-92.00%2025-09-302025-11-14

Put Option Holdings

QURE Put PutUNIQURE NV75.0K sharesnew addition2025-09-302025-11-14

ELDN Put PutELEDON PHARMACEUTICALS INC200.0K sharesnew addition2025-09-302025-11-14