Sponsored

The Analysis of SPHERA FUNDS MANAGEMENT LTD.'s Holdings & P&L

Currently, SPHERA FUNDS MANAGEMENT LTD. holds 92 types of securities in its portfolio with a total value $581.5M. In the most recent quarter, they have increased their positions in MLYS (+891.0K shares, valued at $24.1M), N/A (+62.5K shares, valued at $12.3M), RARE (+508.7K shares, valued at $10.7M); decreased their positions in SEDG (-143.7K shares, valued at $7.3M), ORIC (-466.8K shares, valued at $5.9M), DYN (-232.3K shares, valued at $4.2M); initiated new positions in N/A (+62.5K shares, valued at $12.3M), CLBT (+631.5K shares, valued at $8.7M), PANW (+52.8K shares, valued at $8.5M).

1M P&L

+12.8M+2.67%

3M P&L

+47.4M+10.69%

HY P&L

+102.3M+26.32%

P&L figures are estimated based on reported 13F stock holdings and market price changes. They are approximations and may not reflect actual fund performance. Stock split events may also affect the accuracy of these calculations, and we cannot guarantee that all splits have been fully accounted for.

Top Holding Treemap

Top Industries by Value

1Biotechnology247.2M

57.2%

2Drug Manufacturers - General80.1M

18.5%

3Drug Manufacturers - Specialty & Generic44.8M

10.4%

Top Industries by Stock Count

1Biotechnology52 stocks

67.5%

2Drug Manufacturers - General11 stocks

14.3%

3Drug Manufacturers - Specialty & Generic3 stocks

3.9%

Sponsored

Stock Holdings

TickerCompany NameSharesShares △%Event DateReport DateHistory

MLYS MINERALYS THERAPEUTICS INC1.3M shares198.43%2026-03-312026-05-15

TEVA TEVA PHARMACEUTICAL INDS LTD1.1M shares1.20%2026-03-312026-05-15

TSEM TOWER SEMICONDUCTOR LTD145.7K shares18.95%2026-03-312026-05-15

NVMI NOVA LTD53.4K shares11.54%2026-03-312026-05-15

BBIO BRIDGEBIO PHARMA INC245.2K shares127.61%2026-03-312026-05-15

BIIB BIOGEN INC92.5K shares-2.33%2026-03-312026-05-15

RARE ULTRAGENYX PHARMACEUTICAL IN809.3K shares169.22%2026-03-312026-05-15

SNDX SYNDAX PHARMACEUTICALS INC724.6K shares-4.98%2026-03-312026-05-15

Sponsored

COGT COGENT BIOSCIENCES INC416.3K shares10.00%2026-03-312026-05-15

SNY SANOFI SA269.5K shares12.53%2026-03-312026-05-15

ASTRAZENECA PLC ASTRAZENECA PLC62.5K sharesnew addition2026-03-312026-05-15

FOLD AMICUS THERAPEUTIC603.4K shares-8.35%2026-03-312026-05-15

CLBT CELLEBRITE DI LTD631.5K sharesnew addition2026-03-312026-05-15

APLS APELLIS PHARMACEUTICALS INC214.9K shares-14.36%2026-03-312026-05-15

PANW PALO ALTO NETWORKS INC52.8K sharesnew addition2026-03-312026-05-15

LLY ELI LILLY & CO9.0K shares0.00%2026-03-312026-05-15

Sponsored

BCRX BIOCRYST PHARMACEUTICALS INC866.5K shares3.41%2026-03-312026-05-15

CAMT CAMTEK LTD53.0K shares34.23%2026-03-312026-05-15

BMRN BIOMARIN PHARMACEUTICAL INC139.9K shares-4.83%2026-03-312026-05-15

CLDX CELLDEX THERAPEUTICS INC NEW243.6K shares1.59%2026-03-312026-05-15

ORA ORMAT TECHNOLOGIES INC68.3K sharesnew addition2026-03-312026-05-15

XENE XENON PHARMACEUTICALS INC127.0K sharesnew addition2026-03-312026-05-15

SOLENO THERAPEUTICS INC SOLENO THERAPEUTICS INC216.3K shares58.66%2026-03-312026-05-15

TNGX TANGO THERAPEUTICS INC343.6K shares-36.91%2026-03-312026-05-15

Sponsored

JNJ JOHNSON & JOHNSON28.8K shares-19.54%2026-03-312026-05-15

SOLAREDGE TECHNOLOGIES INC SOLAREDGE TECHNOLOGIES INC4.0M shares0.00%2026-03-312026-05-15

IMTX IMMATICS N.V696.1K shares-19.16%2026-03-312026-05-15

TRVI TREVI THERAPEUTICS INC574.0K shares-4.09%2026-03-312026-05-15

ORIC ORIC PHARMACEUTICALS INC537.6K shares-46.47%2026-03-312026-05-15

MAZE MAZE THERAPEUTICS INC227.3K shares216.44%2026-03-312026-05-15

GSK PLC GSK PLC122.0K shares0.00%2026-03-312026-05-15

AMZN AMAZON COM INC31.9K sharesnew addition2026-03-312026-05-15

Sponsored

ABBV ABBVIE INC30.3K shares19.80%2026-03-312026-05-15

AAOI APPLIED OPTOELECTRONICS INC73.4K sharesnew addition2026-03-312026-05-15

ELVN ENLIVEN THERAPEUTICS INC153.3K shares-32.41%2026-03-312026-05-15

MERCK & CO INC MERCK & CO INC48.6K shares0.00%2026-03-312026-05-15

VOR VOR BIOPHARMA INC321.9K shares-21.56%2026-03-312026-05-15

ACAD ACADIA PHARMACEUTICALS INC256.2K shares20.73%2026-03-312026-05-15

NVS NOVARTIS AG37.0K shares0.00%2026-03-312026-05-15

ELDN ELEDON PHARMACEUTICALS INC1.8M shares-16.88%2026-03-312026-05-15

Sponsored

ENPH ENPHASE ENERGY INC142.4K shares-23.64%2026-03-312026-05-15

RVMD REVOLUTION MEDICINES INC55.1K shares4.97%2026-03-312026-05-15

PFE PFIZER INC186.0K shares116.28%2026-03-312026-05-15

BIOHAVEN LTD BIOHAVEN LTD594.0K sharesnew addition2026-03-312026-05-15

FORTE BIOSCIENCES INC FORTE BIOSCIENCES INC185.0K shares-0.48%2026-03-312026-05-15

CYBN CYBIN INC987.1K shares19.56%2026-03-312026-05-15

MDGL MADRIGAL PHARMACEUTICALS INC9.0K shares173.94%2026-03-312026-05-15

SRRK SCHOLAR ROCK HLDG CORP94.3K shares-40.44%2026-03-312026-05-15

Sponsored

NVO NOVO-NORDISK A S120.7K shares4.32%2026-03-312026-05-15

MEDIWOUND LTD MEDIWOUND LTD273.2K shares18.60%2026-03-312026-05-15

KOD KODIAK SCIENCES INC114.8K shares-34.59%2026-03-312026-05-15

ZBIO ZENAS BIOPHARMA INC214.3K sharesnew addition2026-03-312026-05-15

PROMIS NEUROSCIENCES INC PROMIS NEUROSCIENCES INC325.6K shares2657.61%2026-03-312026-05-15

RLAY RELAY THERAPEUTICS INC408.4K sharesnew addition2026-03-312026-05-15

SVRA SAVARA INC739.2K shares-37.26%2026-03-312026-05-15

WVE WAVE LIFE SCIENCES LTD548.3K shares34.33%2026-03-312026-05-15

Sponsored

CRVS CORVUS PHARMACEUTICALS INC248.0K shares-39.18%2026-03-312026-05-15

OVID OVID THERAPEUTICS INC1.6M sharesnew addition2026-03-312026-05-15

IRON DISC MEDICINE INC53.5K sharesnew addition2026-03-312026-05-15

UPB UPSTREAM BIO INC358.0K sharesnew addition2026-03-312026-05-15

ACOG ALPHA COGNITION INC567.6K shares0.00%2026-03-312026-05-15

PALISADE BIO INC PALISADE BIO INC1.7M shares841.59%2026-03-312026-05-15

DYN DYNE THERAPEUTICS INC160.6K shares-59.13%2026-03-312026-05-15

CLYM CLIMB BIO INC419.2K shares-55.03%2026-03-312026-05-15

Sponsored

ZIM ZIM INTEGRATED SHIPPING SERV106.0K shares-22.10%2026-03-312026-05-15

SATELLOS BIOSCIENCE INC SATELLOS BIOSCIENCE INC489.2K sharesnew addition2026-03-312026-05-15

SEDG SOLAREDGE TECHNOLOGIES INC52.8K shares-73.12%2026-03-312026-05-15

AMGN AMGEN INC7.5K shares0.00%2026-03-312026-05-15

CYTK CYTOKINETICS INC39.8K shares-56.59%2026-03-312026-05-15

GPCR STRUCTURE THERAPEUTICS INC50.8K shares23.90%2026-03-312026-05-15

KURA KURA ONCOLOGY INC295.5K shares0.00%2026-03-312026-05-15

GENERATE BIOMEDICINES INC GENERATE BIOMEDICINES INC185.0K sharesnew addition2026-03-312026-05-15

Sponsored

IBIT ISHARES BITCOIN TRUST ETF59.5K shares97.99%2026-03-312026-05-15

CTNM CONTINEUM THERAPEUTICS INC173.5K shares0.00%2026-03-312026-05-15

TENAX THERAPEUTICS INC TENAX THERAPEUTICS INC136.0K shares-28.45%2026-03-312026-05-15

PRLD PRELUDE THERAPEUTICS INC558.3K shares354.85%2026-03-312026-05-15

ASND ASCENDIS PHARMA A/S8.0K shares-27.27%2026-03-312026-05-15

VERASTEM INC VERASTEM INC343.7K shares0.00%2026-03-312026-05-15

VYGR VOYAGER THERAPEUTICS INC469.8K shares38.26%2026-03-312026-05-15

STTK SHATTUCK LABS INC280.8K shares43.84%2026-03-312026-05-15

Sponsored

EVOMMUNE INC EVOMMUNE INC78.2K shares-52.91%2026-03-312026-05-15

BIOA BIOAGE LABS INC86.5K shares-64.40%2026-03-312026-05-15

ORGO ORGANOGENESIS HLDGS INC550.0K sharesnew addition2026-03-312026-05-15

CURIS INC CURIS INC2.0M sharesnew addition2026-03-312026-05-15

BMY BRISTOL-MYERS SQUIBB CO17.5K shares0.00%2026-03-312026-05-15

CTMX CYTOMX THERAPEUTICS INC.220.0K sharesnew addition2026-03-312026-05-15

NICE NICE LTD5.6K sharesnew addition2026-03-312026-05-15

HOWL WEREWOLF THERAPEUTICS INC626.8K shares0.00%2026-03-312026-05-15

Sponsored

SKYE BIOSCIENCE INC SKYE BIOSCIENCE INC678.9K shares41.76%2026-03-312026-05-15

PRECISION BIOSCIENCES INC PRECISION BIOSCIENCES INC40.0K shares-89.90%2026-03-312026-05-15

APREA THERAPEUTICS INC APREA THERAPEUTICS INC270.0K shares0.00%2026-03-312026-05-15

FHTX FOGHORN THERAPEUTICS INC12.2K sharesnew addition2026-03-312026-05-15

MLYS

MINERALYS THERAPEUTICS INC

198.43%

Shares1.3M

Event2026-03-31

Filed2026-05-15

TEVA

TEVA PHARMACEUTICAL INDS LTD

1.20%

Shares1.1M

Event2026-03-31

Filed2026-05-15

TSEM

TOWER SEMICONDUCTOR LTD

18.95%

Shares145.7K

Event2026-03-31

Filed2026-05-15

NVMI

NOVA LTD

11.54%

Shares53.4K

Event2026-03-31

Filed2026-05-15

BBIO

BRIDGEBIO PHARMA INC

127.61%

Shares245.2K

Event2026-03-31

Filed2026-05-15

BIIB

BIOGEN INC

-2.33%

Shares92.5K

Event2026-03-31

Filed2026-05-15

RARE

ULTRAGENYX PHARMACEUTICAL IN

169.22%

Shares809.3K

Event2026-03-31

Filed2026-05-15

SNDX

SYNDAX PHARMACEUTICALS INC

-4.98%

Shares724.6K

Event2026-03-31

Filed2026-05-15

COGT

COGENT BIOSCIENCES INC

10.00%

Shares416.3K

Event2026-03-31

Filed2026-05-15

SNY

SANOFI SA

12.53%

Shares269.5K

Event2026-03-31

Filed2026-05-15

ASTRAZENECA PLC

New

Shares62.5K

Event2026-03-31

Filed2026-05-15

FOLD

AMICUS THERAPEUTIC

-8.35%

Shares603.4K

Event2026-03-31

Filed2026-05-15

CLBT

CELLEBRITE DI LTD

New

Shares631.5K

Event2026-03-31

Filed2026-05-15

APLS

APELLIS PHARMACEUTICALS INC

-14.36%

Shares214.9K

Event2026-03-31

Filed2026-05-15

PANW

PALO ALTO NETWORKS INC

New

Shares52.8K

Event2026-03-31

Filed2026-05-15

LLY

ELI LILLY & CO

0.00%

Shares9.0K

Event2026-03-31

Filed2026-05-15

BCRX

BIOCRYST PHARMACEUTICALS INC

3.41%

Shares866.5K

Event2026-03-31

Filed2026-05-15

CAMT

CAMTEK LTD

34.23%

Shares53.0K

Event2026-03-31

Filed2026-05-15

BMRN

BIOMARIN PHARMACEUTICAL INC

-4.83%

Shares139.9K

Event2026-03-31

Filed2026-05-15

CLDX

CELLDEX THERAPEUTICS INC NEW

1.59%

Shares243.6K

Event2026-03-31

Filed2026-05-15

ORA

ORMAT TECHNOLOGIES INC

New

Shares68.3K

Event2026-03-31

Filed2026-05-15

XENE

XENON PHARMACEUTICALS INC

New

Shares127.0K

Event2026-03-31

Filed2026-05-15

SOLENO THERAPEUTICS INC

58.66%

Shares216.3K

Event2026-03-31

Filed2026-05-15

TNGX

TANGO THERAPEUTICS INC

-36.91%

Shares343.6K

Event2026-03-31

Filed2026-05-15

JNJ

JOHNSON & JOHNSON

-19.54%

Shares28.8K

Event2026-03-31

Filed2026-05-15

SOLAREDGE TECHNOLOGIES INC

0.00%

Shares4.0M

Event2026-03-31

Filed2026-05-15

IMTX

IMMATICS N.V

-19.16%

Shares696.1K

Event2026-03-31

Filed2026-05-15

TRVI

TREVI THERAPEUTICS INC

-4.09%

Shares574.0K

Event2026-03-31

Filed2026-05-15

ORIC

ORIC PHARMACEUTICALS INC

-46.47%

Shares537.6K

Event2026-03-31

Filed2026-05-15

MAZE

MAZE THERAPEUTICS INC

216.44%

Shares227.3K

Event2026-03-31

Filed2026-05-15

GSK PLC

0.00%

Shares122.0K

Event2026-03-31

Filed2026-05-15

AMZN

AMAZON COM INC

New

Shares31.9K

Event2026-03-31

Filed2026-05-15

ABBV

ABBVIE INC

19.80%

Shares30.3K

Event2026-03-31

Filed2026-05-15

AAOI

APPLIED OPTOELECTRONICS INC

New

Shares73.4K

Event2026-03-31

Filed2026-05-15

ELVN

ENLIVEN THERAPEUTICS INC

-32.41%

Shares153.3K

Event2026-03-31

Filed2026-05-15

MERCK & CO INC

0.00%

Shares48.6K

Event2026-03-31

Filed2026-05-15

VOR

VOR BIOPHARMA INC

-21.56%

Shares321.9K

Event2026-03-31

Filed2026-05-15

ACAD

ACADIA PHARMACEUTICALS INC

20.73%

Shares256.2K

Event2026-03-31

Filed2026-05-15

NVS

NOVARTIS AG

0.00%

Shares37.0K

Event2026-03-31

Filed2026-05-15

ELDN

ELEDON PHARMACEUTICALS INC

-16.88%

Shares1.8M

Event2026-03-31

Filed2026-05-15

ENPH

ENPHASE ENERGY INC

-23.64%

Shares142.4K

Event2026-03-31

Filed2026-05-15

RVMD

REVOLUTION MEDICINES INC

4.97%

Shares55.1K

Event2026-03-31

Filed2026-05-15

PFE

PFIZER INC

116.28%

Shares186.0K

Event2026-03-31

Filed2026-05-15

BIOHAVEN LTD

New

Shares594.0K

Event2026-03-31

Filed2026-05-15

FORTE BIOSCIENCES INC

-0.48%

Shares185.0K

Event2026-03-31

Filed2026-05-15

CYBN

CYBIN INC

19.56%

Shares987.1K

Event2026-03-31

Filed2026-05-15

MDGL

MADRIGAL PHARMACEUTICALS INC

173.94%

Shares9.0K

Event2026-03-31

Filed2026-05-15

SRRK

SCHOLAR ROCK HLDG CORP

-40.44%

Shares94.3K

Event2026-03-31

Filed2026-05-15

NVO

NOVO-NORDISK A S

4.32%

Shares120.7K

Event2026-03-31

Filed2026-05-15

MEDIWOUND LTD

18.60%

Shares273.2K

Event2026-03-31

Filed2026-05-15

KOD

KODIAK SCIENCES INC

-34.59%

Shares114.8K

Event2026-03-31

Filed2026-05-15

ZBIO

ZENAS BIOPHARMA INC

New

Shares214.3K

Event2026-03-31

Filed2026-05-15

PROMIS NEUROSCIENCES INC

2657.61%

Shares325.6K

Event2026-03-31

Filed2026-05-15

RLAY

RELAY THERAPEUTICS INC

New

Shares408.4K

Event2026-03-31

Filed2026-05-15

SVRA

SAVARA INC

-37.26%

Shares739.2K

Event2026-03-31

Filed2026-05-15

WVE

WAVE LIFE SCIENCES LTD

34.33%

Shares548.3K

Event2026-03-31

Filed2026-05-15

CRVS

CORVUS PHARMACEUTICALS INC

-39.18%

Shares248.0K

Event2026-03-31

Filed2026-05-15

OVID

OVID THERAPEUTICS INC

New

Shares1.6M

Event2026-03-31

Filed2026-05-15

IRON

DISC MEDICINE INC

New

Shares53.5K

Event2026-03-31

Filed2026-05-15

UPB

UPSTREAM BIO INC

New

Shares358.0K

Event2026-03-31

Filed2026-05-15

ACOG

ALPHA COGNITION INC

0.00%

Shares567.6K

Event2026-03-31

Filed2026-05-15

PALISADE BIO INC

841.59%

Shares1.7M

Event2026-03-31

Filed2026-05-15

DYN

DYNE THERAPEUTICS INC

-59.13%

Shares160.6K

Event2026-03-31

Filed2026-05-15

CLYM

CLIMB BIO INC

-55.03%

Shares419.2K

Event2026-03-31

Filed2026-05-15

ZIM

ZIM INTEGRATED SHIPPING SERV

-22.10%

Shares106.0K

Event2026-03-31

Filed2026-05-15

SATELLOS BIOSCIENCE INC

New

Shares489.2K

Event2026-03-31

Filed2026-05-15

SEDG

SOLAREDGE TECHNOLOGIES INC

-73.12%

Shares52.8K

Event2026-03-31

Filed2026-05-15

AMGN

AMGEN INC

0.00%

Shares7.5K

Event2026-03-31

Filed2026-05-15

CYTK

CYTOKINETICS INC

-56.59%

Shares39.8K

Event2026-03-31

Filed2026-05-15

GPCR

STRUCTURE THERAPEUTICS INC

23.90%

Shares50.8K

Event2026-03-31

Filed2026-05-15

KURA

KURA ONCOLOGY INC

0.00%

Shares295.5K

Event2026-03-31

Filed2026-05-15

GENERATE BIOMEDICINES INC

New

Shares185.0K

Event2026-03-31

Filed2026-05-15

IBIT

ISHARES BITCOIN TRUST ETF

97.99%

Shares59.5K

Event2026-03-31

Filed2026-05-15

CTNM

CONTINEUM THERAPEUTICS INC

0.00%

Shares173.5K

Event2026-03-31

Filed2026-05-15

TENAX THERAPEUTICS INC

-28.45%

Shares136.0K

Event2026-03-31

Filed2026-05-15

PRLD

PRELUDE THERAPEUTICS INC

354.85%

Shares558.3K

Event2026-03-31

Filed2026-05-15

ASND

ASCENDIS PHARMA A/S

-27.27%

Shares8.0K

Event2026-03-31

Filed2026-05-15

VERASTEM INC

0.00%

Shares343.7K

Event2026-03-31

Filed2026-05-15

VYGR

VOYAGER THERAPEUTICS INC

38.26%

Shares469.8K

Event2026-03-31

Filed2026-05-15

STTK

SHATTUCK LABS INC

43.84%

Shares280.8K

Event2026-03-31

Filed2026-05-15

EVOMMUNE INC

-52.91%

Shares78.2K

Event2026-03-31

Filed2026-05-15

BIOA

BIOAGE LABS INC

-64.40%

Shares86.5K

Event2026-03-31

Filed2026-05-15

ORGO

ORGANOGENESIS HLDGS INC

New

Shares550.0K

Event2026-03-31

Filed2026-05-15

CURIS INC

New

Shares2.0M

Event2026-03-31

Filed2026-05-15

BMY

BRISTOL-MYERS SQUIBB CO

0.00%

Shares17.5K

Event2026-03-31

Filed2026-05-15

CTMX

CYTOMX THERAPEUTICS INC.

New

Shares220.0K

Event2026-03-31

Filed2026-05-15

NICE

NICE LTD

New

Shares5.6K

Event2026-03-31

Filed2026-05-15

HOWL

WEREWOLF THERAPEUTICS INC

0.00%

Shares626.8K

Event2026-03-31

Filed2026-05-15

SKYE BIOSCIENCE INC

41.76%

Shares678.9K

Event2026-03-31

Filed2026-05-15

PRECISION BIOSCIENCES INC

-89.90%

Shares40.0K

Event2026-03-31

Filed2026-05-15

APREA THERAPEUTICS INC

0.00%

Shares270.0K

Event2026-03-31

Filed2026-05-15

FHTX

FOGHORN THERAPEUTICS INC

New

Shares12.2K

Event2026-03-31

Filed2026-05-15

Call Option Holdings

CYTK Call CallCYTOKINETICS INC259.3K sharesnew addition2026-03-312026-05-15

TLT Call CallISHARES TR47.0K shares0.00%2026-03-312026-05-15

OLMA Call CallOLEMA PHARMACEUTICALS INC100.0K sharesnew addition2026-03-312026-05-15

CYTK Call

CYTOKINETICS INC

New

Shares259.3K

Event2026-03-31

Filed2026-05-15

TLT Call

ISHARES TR

0.00%

Shares47.0K

Event2026-03-31

Filed2026-05-15

OLMA Call

OLEMA PHARMACEUTICALS INC

New

Shares100.0K

Event2026-03-31

Filed2026-05-15

Put Option Holdings

XBI Put PutSPDR SERIES TRUST200.0K shares185.71%2026-03-312026-05-15

XBI Put

SPDR SERIES TRUST

185.71%

Shares200.0K

Event2026-03-31

Filed2026-05-15