Schedule 13D Filing for NuCana plc

Hugh S. Griffith, CEO of NuCana plc, reported beneficial ownership of 2,829,961,890 ordinary shares, representing 12.0% of the outstanding shares as of March 18, 2026. This includes 1,000,000 directly owned shares, 265,026 ADSs, and options to purchase 2,828,696,864 ordinary shares exercisable within 60 days of March 18, 2026. Griffith acquired his directly owned shares in 2008 using personal funds and the ADSs in the open market in 2021 and 2022. The options were granted as compensation in connection with his role as CEO. The filing was made after the deadline due to inadvertent administrative oversight, compounded by the Reporting Person undergoing surgery and treatment for a serious illness. Griffith acquired securities for investment purposes and may influence corporate activities but currently has no specific plans outlined in Schedule 13D. Transactions since crossing the 5% threshold include options granted on June 20, 2025, and January 14, 2026. No borrowed funds were used.