FMR LLC Acquires 14.4% Stake in Tyra Biosciences Inc.

FMR LLC, along with Abigail P. Johnson, has filed a Schedule 13G reporting a significant new ownership stake in Tyra Biosciences Inc. (TYRA). As of March 31, 2026, the filers beneficially own 7,747,647.96 shares of common stock, representing a 14.4% ownership interest in the company. This position marks a substantial increase from a previous 0% holding, establishing FMR LLC as a major institutional shareholder. The filing indicates that FMR LLC holds sole dispositive power over the entire share amount, while holding sole voting power over 7,741,957 shares. Notably, Fidelity OTC Portfolio is identified as a specific entity within the FMR structure holding 2,694,729 shares, or approximately 5.0% of the total outstanding common stock. The securities were acquired in the ordinary course of business and not for the purpose of influencing or changing the control of the issuer. This move signals a strong institutional commitment to Tyra Biosciences by one of the world's largest asset managers.