CMLS Holdings LLC and Affiliates Increase Stake in GeneDx Holdings Corp. via Open Market Purchases

On May 15, 2026, CMLS Holdings LLC filed Amendment No. 11 to its Schedule 13D, reporting an increased position in GeneDx Holdings Corp. (WGS). The filing indicates that CMLS Holdings LLC now beneficially owns 537,285 shares of Class A common stock, representing 1.8% of the class. This position is held jointly through a complex structure involving Eli Casdin and Keith Meister, who share voting and investment discretion. The amendment highlights significant activity by related reporting persons. Keith Meister, through Corvex Management LP, has substantially increased his indirect beneficial ownership via open market purchases occurring between May 13 and May 15, 2026, at prices ranging from approximately $38.28 to $39.92 per share. Following these transactions, Keith Meister's total beneficial ownership stands at 5,356,767 shares (17.9%), while Eli Casdin reports beneficial ownership of 3,599,671 shares (12.0%). The shares held by CMLS Holdings include 333,144 shares of Class A common stock and 204,141 shares issuable upon the exercise of private placement warrants.