Amendment to Merger Agreement

Shuttle Pharmaceuticals Holdings, Inc. has entered into a First Amendment to Merger Agreement with United Dogecoin Inc. The amendment modifies the definition of "Milestone Event" by reducing the required number of Mining Rigs from 2,000 to 500. This change does not affect other terms of the original Merger Agreement, including the maximum number of warrants issuable upon satisfaction of the Milestone Event. The company is also seeking similar amendments to its Securities Purchase Agreement and an Asset Purchase Agreement to align the "Milestone Event" definition across these agreements. These amendments are subject to approval from the respective parties. The filing also includes standard forward-looking statement disclaimers regarding the success and timing of these amendment efforts.