Rhythm Pharmaceuticals, Inc. - Officer and Director Change

On December 16, 2025, Camille L. Bedrosian, M.D. resigned from the Board of Directors of Rhythm Pharmaceuticals, Inc. Dr. Bedrosian was a member of the Compensation & Management Development Committee and the Governance and Nominating Committee. Her resignation was not prompted by any disagreements regarding the Company's operations, policies, or practices. The company appointed Hunter C. Smith, Chief Financial Officer, to sign the report on its behalf.