RA Capital Management Establishes 9.9% Stake in OnKure Therapeutics, Inc. (OKUR)

On April 7, 2026, RA Capital Management, L.P., along with Peter Kolchinsky, Rajeev Shah, and RA Capital Healthcare Fund, L.P., filed a Schedule 13G reporting a new 9.9% stake in OnKure Therapeutics, Inc. (OKUR). The reporting persons collectively beneficially own 4,038,715 shares of Class A common stock. This position was established following a private placement that closed on March 31, 2026. The holding consists of 3,998,332 shares of Class A common stock and pre-funded warrants. The total ownership is subject to a 9.99% Beneficial Ownership Blocker, which limits the exercise of the warrants to ensure the group's total ownership does not exceed that threshold. Due to EDGAR system limitations, the 9.99% ownership is reported as 9.9% on the filing cover pages. RA Capital serves as the investment adviser to the Fund, with Dr. Kolchinsky and Mr. Shah acting as controlling persons. The filing indicates the shares were acquired for investment purposes and not to influence control of the issuer.