Power of Attorney Filing

This filing is an exhibit of a Limited Power of Attorney for securities law compliance. Liam Ratcliffe, a director of OnKure Therapeutics, Inc., has appointed Jason Leverone and Rogan Nunn as his attorneys-in-fact. They are authorized to execute and file necessary forms, including Forms 144, ID, 3, 4, and 5, with regulatory bodies like the SEC and stock exchanges. This authorization is required due to Ratcliffe's ownership, acquisition, or disposition of the Corporation's securities. The power of attorney remains effective until Ratcliffe is no longer obligated to file these forms or until he revokes it in writing. The document emphasizes that the attorneys-in-fact and the Corporation are not assuming Ratcliffe's responsibility for Section 16 compliance.