New Enterprise Associates Exits Reporting Status in Inventiva S.A. Following Share Dilution

This Amendment No. 4 to Schedule 13D is being filed by New Enterprise Associates (NEA) and its affiliated entities regarding their investment in Inventiva S.A. (IVA). The filing reflects an exit from reporting status by the Reporting Persons as of November 17, 2025. This change resulted from an increase in the total number of the Issuer's outstanding Ordinary Shares, which diluted the Reporting Persons' combined beneficial ownership to 4.9%, falling below the 5% threshold required for Schedule 13D reporting. The Reporting Persons collectively hold 9,372,390 shares, which includes 6,684,064 Ordinary Shares held of record by NEA 17, 1,666,666 shares held by Growth Equity Opportunities 18 VGE, LLC, and 1,021,660 shares underlying various warrants and pre-funded warrants. The percentage calculation is based on 186,801,792 Ordinary Shares outstanding as of December 31, 2025. No transactions were effected by the Reporting Persons in the 60 days preceding this filing. The group maintains its position for investment purposes but is no longer subject to the reporting requirements of Section 13(d).