Director Peter N. Reikes Reports No Securities Ownership in Ionis Pharmaceuticals

This Form 3 filing reports that Peter N. Reikes, a director of Ionis Pharmaceuticals Inc., has no securities ownership in the company as of June 4, 2026. The filing was submitted on June 5, 2026, and signed by attorney-in-fact Patrick R. O'Neil on behalf of Mr. Reikes. The document indicates that Mr. Reikes serves as a director of the company but is not an officer, ten percent owner, or other type of reporting person. This initial statement of beneficial ownership shows zero securities held, which is unusual for a director but may indicate that Mr. Reikes has not yet acquired any company securities following his appointment or has disposed of all holdings prior to this reporting period.