Initial Statement of Beneficial Ownership

This filing is an initial statement of beneficial ownership filed by Robert J. Spiegel, a director at Ernexa Therapeutics Inc. (ERNA). The report indicates that Mr. Spiegel has no securities owned. The filing date was September 22, 2026, with the period of report being September 14, 2026. The address provided for the reporting owner is in Cambridge, MA. This type of filing (Form 3) is typically made when a person becomes a company insider, such as a director or a 10% owner, and reports their initial ownership of securities.