Form 3 Filing for David Shapiro

This filing is a Form 3, which reports initial beneficial ownership of securities. David Shapiro, a director at Design Therapeutics, Inc., has appointed Mustapha Parekh and Sean Jeffries as his attorneys-in-fact to execute and file Forms 3, 4, and 5 on his behalf. This power of attorney remains in effect until Shapiro is no longer required to file these forms, or until it is revoked or the attorneys-in-fact leave the company. The filing indicates Shapiro is a director but not a 10% owner or officer. The report is for the period ending March 31, 2026.