BIOHARVEST SCIENCES INC. - Material Change Report

BioHarvest Sciences Inc. has announced a significant development with a US $1.4 million grant from the Israel Innovation Authority (IIA). This non-dilutive funding will support a new research initiative focused on integrating advanced data science, machine learning, and computer vision into the company's plant cell culture programs. The initiative aims to move from traditional trial-and-error methods to a data-driven optimization framework, utilizing bioinformatics, chemo-informatics, and AI to predict success and maximize active metabolite yields. This program will accelerate the development of BioHarvest's computational discovery engine, enabling rapid identification of optimal pathways and maximizing bioactive yields. This is the second grant from the IIA this year, with the first focused on scaling manufacturing. This grant is specifically for transforming early-stage R&D through predictive AI, bridging the gap between laboratory discovery and commercial production. The grant is a zero-interest loan, with repayment contingent on commercial milestones and expected to be funded by future revenues.