Form 4 Filing for BIOCRYST PHARMACEUTICALS INC

This filing details transactions made by Alane P. Barnes, Chief Legal Officer of BIOCRYST PHARMACEUTICALS INC, on December 19, 2025, and December 22, 2025. On December 19, 2025, 16,902 shares of Common Stock were withheld to satisfy tax obligations related to the vesting of restricted stock units. This was a non-discretionary event and did not involve a sale. Following this transaction, 420,524 shares were held. On December 22, 2025, 21,773 shares of Common Stock were disposed of under a Rule 10b5-1 trading plan adopted on August 13, 2025. This transaction was also automatic and not discretionary. After this disposal, 398,751 shares remained in holdings. All transactions were reported as direct ownership.