Amendment to Schedule 13D Filing for BICARA THERAPEUTICS INC.

This filing is an amendment to a previously filed Schedule 13D by RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, and RA Capital Healthcare Fund, L.P. (collectively, the "Reporting Persons"). The amendment supplements information regarding the ownership of BICARA THERAPEUTICS INC. common stock. On February 26, 2026, RA Capital Healthcare Fund, L.P. purchased 300,000 shares of common stock at $16.00 per share and 2,200,000 pre-funded warrants at $15.9999 per warrant, for a total of $39,999,780, funded by working capital. The Reporting Persons collectively hold 7,279,739 shares, representing 11.5% of the outstanding common stock. RA Capital Management, L.P. has shared voting and dispositive power over these shares.